Human PRDX2 Recombinant Protein (RPPB2176)
- SKU:
- RPPB2176
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- P32119
- Research Area:
- Enzymes
Description
| Product Name: | Human PRDX2 Recombinant Protein |
| Product Code: | RPPB2176 |
| Size: | 20µg |
| Species: | Human |
| Target: | PRDX2 |
| Synonyms: | PRP, TSA, PRX2, NKEFB, PRXII, TDPX1, MGC4104, PRDX2, Peroxiredoxin-2, Thioredoxin peroxidase 1, Thioredoxin-dependent peroxide reductase 1, Thiol-specific antioxidant protein, Natural killer cell-enhancing factor B, NKEF-B. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | The Peroxiredoxin solution contains 20mM Tris-HCl pH-8, & 10% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 90.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MASGNARIGK PAPDFKATAV VDGAFKEVKL SDYKGKYVVL FFYPLDFTFV CPTEIIAFSN RAEDFRKLGC EVLGVSVDSQ FTHLAWINTP RKEGGLGPLN IPLLADVTRR LSEDYGVLKT DEGIAYRGLF IIDGKGVLRQ ITVNDLPVGR SVDEALRLVQ AFQYTDEHGE VCPAGWKPGS DTIKPNVDDS KEYFSKHN |
| Biological Activity: | The specific activity was found to be approximately 200-230 pmole/min/�g.The enzymatic activity was confirmed by measuring the remaining peroxide after incubation of PRDX2 and peroxide for 20 min at room temperature. Specific activity is defined as the amount of hydroperoxide that 1ug of enzyme can reduce at 25�C for 1 minute. |
PRDX2 is part of the peroxiredoxin family of antioxidant enzymes, which reduce hydrogen peroxide and alkyl hydroperoxides. PRDX2 takes part as an antioxidant protective role in cells, and contributes to the antiviral activity of CD8(+) T-cells. PRDX2 has proliferative effect in cancer development or progression. If PRDX2 protection is insufficient against peroxidases, the DNA damage results in neurological disease such as Alzheimer's or DNA damage leading to cancer.
PRDX2 Human Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 198 amino acids and having a molecular mass of 21.8 kDa.The PRDX2 is purified by proprietary chromatographic techniques.
| UniProt Protein Function: | PRDX2: a member of the peroxiredoxin family of antioxidant enzymes, which reduce hydrogen peroxide and alkyl hydroperoxides. Involved in redox regulation of the cell. Reduces peroxides with reducing equivalents provided through the thioredoxin system but not from glutaredoxin. May play an important role in eliminating peroxides generated during metabolism. Might participate in the signaling cascades of growth factors and tumor necrosis factor-alpha by regulating the intracellular concentrations of H(2)O(2). May have a proliferative effect and play a role in cancer development or progression. Three splice-variant isoforms have been identified. |
| UniProt Protein Details: | Protein type:Oxidoreductase; EC 1.11.1.15 Chromosomal Location of Human Ortholog: 19p13.2 Cellular Component: cytoplasm; cytosol Molecular Function:antioxidant activity; thioredoxin peroxidase activity Biological Process: regulation of apoptosis; response to reactive oxygen species; removal of superoxide radicals; hydrogen peroxide catabolic process; response to oxidative stress; negative regulation of neuron apoptosis; negative regulation of apoptosis |
| NCBI Summary: | This gene encodes a member of the peroxiredoxin family of antioxidant enzymes, which reduce hydrogen peroxide and alkyl hydroperoxides. The encoded protein plays an antioxidant protective role in cells, and it may contribute to the antiviral activity of CD8(+) T-cells. The crystal structure of this protein has been resolved to 2.7 angstroms. This protein prevents hemolytic anemia from oxidative stress by stabilizing hemoglobin, thus making this gene a therapeutic target for patients with hemolytic anemia. This protein may have a proliferative effect and play a role in cancer development or progression. Related pseudogenes have been identified on chromosomes 5, 6, 10 and 13. [provided by RefSeq, Mar 2013] |
| UniProt Code: | P32119 |
| NCBI GenInfo Identifier: | 2507169 |
| NCBI Gene ID: | 7001 |
| NCBI Accession: | P32119.5 |
| UniProt Secondary Accession: | P32119,P31945, P32118, P35701, Q6FHG4, Q92763, Q9UC23 A8K0C0, |
| UniProt Related Accession: | P32119 |
| Molecular Weight: | 198 |
| NCBI Full Name: | Peroxiredoxin-2 |
| NCBI Synonym Full Names: | peroxiredoxin 2 |
| NCBI Official Symbol: | PRDX2�� |
| NCBI Official Synonym Symbols: | PRP; TSA; PRX2; PTX1; TPX1; NKEFB; PRXII; TDPX1; NKEF-B; HEL-S-2a�� |
| NCBI Protein Information: | peroxiredoxin-2; torin; thioredoxin peroxidase 1; thiol-specific antioxidant 1; natural killer cell-enhancing factor B; thioredoxin-dependent peroxide reductase 1; epididymis secretory sperm binding protein Li 2a |
| UniProt Protein Name: | Peroxiredoxin-2 |
| UniProt Synonym Protein Names: | Natural killer cell-enhancing factor B; NKEF-B; PRP; Thiol-specific antioxidant protein; TSA; Thioredoxin peroxidase 1; Thioredoxin-dependent peroxide reductase 1 |
| Protein Family: | Peroxiredoxin |
| UniProt Gene Name: | PRDX2�� |
| UniProt Entry Name: | PRDX2_HUMAN |
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