Human PRAP1 Recombinant Protein (RPPB4288)
- SKU:
- RPPB4288
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- Q96NZ9
Description
| Product Name: | Human PRAP1 Recombinant Protein |
| Product Code: | RPPB4288 |
| Size: | 10µg |
| Species: | Human |
| Target: | PRAP1 |
| Synonyms: | Proline-rich acidic protein 1, Epididymis tissue protein Li 178, Uterine-specific proline-rich acidic protein, PRAP1, UPA, PRO1195. |
| Source: | Escherichia Coli |
| Physical Appearance: | Filtered White lyophilized (freeze-dried) powder. |
| Formulation: | PRAP1 filtered (0.4 �m) and lyophilized from 0.5mg/ml in 0.05M phosphate buffer and 0.075M NaCl, pH 7.4. |
| Solubility: | It is recommended to add 200�l deionized water to prepare a working stock solution of approximately 0.5mg/ml and let the lyophilized pellet dissolve completely. PRAP1 is not sterile! Please filter the product by an appropriate sterile filter before using it in the cell culture. |
| Stability: | Store lyophilized protein at -20°C. Aliquot the product after reconstitution to avoid repeated freezing/thawing cycles. Reconstituted protein can be stored at 4°C for a limited period of time; it does not show any change after two weeks at 4°C. |
| Purity: | Greater than 85.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MKHHHHHHASVPAPKVPIKM QVKHWPSEQD PEKAWGARVV EPPEKDDQLV VLFPVQKPKL LTTEEKPRGQ GRGPILPGTK AWMETEDTLG HVLSPEPDHD SLYHPPPEED QGEERPRLWV MPNHQVLLGP EEDQDHIYHP Q |
Proline-rich acidic protein 1 (PRAP1) is essential for maintaining homeostasis in epithelial cells e.g. in liver or gastrointestinal tract. PRAP1 is abundantly expressed in the epithelial cells of the liver, kidney, gastrointestinal tract and cervix. PRAP1 is notably down-regulated in hepatocellular carcinoma and right colon adenocarcinoma compared with the respective adjacent normal tissues.
PRAP1 Human Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain (a.a 21-151) containing 141 amino acids including a 10 a.a N-terminal His tag. The total molecular mass is 16.2kDa (calculated).
| UniProt Protein Function: | PRAP1: May play an important role in maintaining normal growth homeostasis in epithelial cells. 4 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Secreted; Secreted, signal peptide Chromosomal Location of Human Ortholog: 10q26.3 Cellular Component: extracellular region Molecular Function:protein binding |
| UniProt Code: | Q96NZ9 |
| NCBI GenInfo Identifier: | 223633959 |
| NCBI Gene ID: | 118471 |
| NCBI Accession: | NP_660203.3 |
| UniProt Secondary Accession: | Q96NZ9,Q5VWY4, Q7Z4X5, Q8IWR3, Q8NCS2, B7ZL57, B7ZL58 E9KL31, |
| UniProt Related Accession: | Q96NZ9 |
| Molecular Weight: | 16,332 Da |
| NCBI Full Name: | proline-rich acidic protein 1 isoform 1 |
| NCBI Synonym Full Names: | proline-rich acidic protein 1 |
| NCBI Official Symbol: | PRAP1�� |
| NCBI Official Synonym Symbols: | UPA; PRO1195�� |
| NCBI Protein Information: | proline-rich acidic protein 1 |
| UniProt Protein Name: | Proline-rich acidic protein 1 |
| UniProt Synonym Protein Names: | Epididymis tissue protein Li 178; Uterine-specific proline-rich acidic protein |
| Protein Family: | Proline-rich acidic protein |
| UniProt Gene Name: | PRAP1�� |
| UniProt Entry Name: | PRAP1_HUMAN |
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