Human PPP4C Recombinant Protein (RPPB2173)
- SKU:
- RPPB2173
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- P60510
- Research Area:
- Enzymes
Description
| Product Name: | Human PPP4C Recombinant Protein |
| Product Code: | RPPB2173 |
| Size: | 20µg |
| Species: | Human |
| Target: | PPP4C |
| Synonyms: | Serine/threonine-protein phosphatase 4 catalytic subunit,PP4, PP4C, PPH3, PPP4, PPX, PPP4C, Protein Phosphatase 4 Catalytic subunit, Proteinphosphatase X, PP-X, Pp4. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | The PPP4C solution (1mg/1ml) contains 20mM Tris-HClbuffer (pH 8.0), 0.4M Urea and 10% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 90% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MGSMAEISDL DRQIEQLRRC ELIKESEVKA LCAKAREILV EESNVQRVDSPVTVCGDIHG QFYDLKELFR VGGDVPETNY LFMGDFVDRG FYSVETFLLL LALKVRYPDR ITLIRGNHESRQITQVYGFY DECLRKYGSV TVWRYCTEIF DYLSLSAIID GKIFCVHGGL SPSIQTLDQI RTIDRKQEVPHDGPMCDLLW SDPEDTTGWG VSPRGAGYLF GSDVVAQFNA ANDIDMICRA HQLVMEGYKW HFNETVLTVWSAPNYCYRCG NVAAILELDE HLQKDFIIFE AAPQETRGIP SKKPVADYFL |
Protein Phosphatase 4 Catalytic subunit (PPP4C), is a part of the Serine/threonine-protein phosphatase catalytic subunits which tskes part in dephosphorylation and regulation of HDAC3. The protein phosphatase (PP) holoenzyme is a trimeric complex compound of a regulatory subunit, a variable subunit and a catalytic subunit. 4 major families of protein phosphatase catalytic subunits have been identified, designated PP1, PP2A, PP2B (calcineurin) and PP2C.
PPP4C Human Recombinant produced in E. coli is a single polypeptidechain containing 330 amino acids (1-307) and having a molecular mass of 37.5kDa. PPP4C is fused to a 23 amino acid His-tag at N-terminus& purified by proprietary chromatographic techniques.
| UniProt Protein Function: | PPP4C: a Ser/Thr phosphatase. A positive regulator of HPK1 and the HPK1-JNK signaling pathway. Mediates TNF-alpha-induced degradation of IRS-4 and plays a role in NF-kappaB p65 Thr dephosphorylation. Holoenzyme consists at least of a catalytic subunit PPP4C and a regulatory subunit PPP4R1. |
| UniProt Protein Details: | Protein type:EC 3.1.3.16; Protein phosphatase, Ser/Thr (non-receptor) Chromosomal Location of Human Ortholog: 16p11.2 Cellular Component: nucleoplasm; cytoplasm; plasma membrane; microtubule organizing center; nucleus Molecular Function:NF-kappaB-inducing kinase activity; protein binding; metal ion binding; protein serine/threonine phosphatase activity Biological Process: dephosphorylation |
| UniProt Code: | P60510 |
| NCBI GenInfo Identifier: | 44888846 |
| NCBI Gene ID: | 5531 |
| NCBI Accession: | P60510.1 |
| UniProt Secondary Accession: | P60510,P33172, |
| UniProt Related Accession: | P60510 |
| Molecular Weight: | 307 |
| NCBI Full Name: | Serine/threonine-protein phosphatase 4 catalytic subunit |
| NCBI Synonym Full Names: | protein phosphatase 4, catalytic subunit |
| NCBI Official Symbol: | PPP4C�� |
| NCBI Official Synonym Symbols: | PP4; PPX; PP-X; PP4C; PPH3; PPP4�� |
| NCBI Protein Information: | serine/threonine-protein phosphatase 4 catalytic subunit; protein phosphatase X, catalytic subunit; protein phosphatase 4 (formerly X), catalytic subunit |
| UniProt Protein Name: | Serine/threonine-protein phosphatase 4 catalytic subunit |
| UniProt Synonym Protein Names: | Protein phosphatase X; PP-X |
| UniProt Gene Name: | PPP4C�� |
| UniProt Entry Name: | PP4C_HUMAN |
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