Human PPP1R3B Recombinant Protein (RPPB4285)
- SKU:
- RPPB4285
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- Q86XI6
Description
| Product Name: | Human PPP1R3B Recombinant Protein |
| Product Code: | RPPB4285 |
| Size: | 20µg |
| Species: | Human |
| Target: | PPP1R3B |
| Synonyms: | Protein phosphatase 1 regulatory subunit 3B, Hepatic glycogen-targeting protein phosphatase 1 regulatory subunit GL, Protein phosphatase 1 regulatory subunit 4, PP1 subunit R4, Protein phosphatase 1 subunit GL, PTG, PPP1R4, PPP1R3B, Protein Phosphatase 1, Regulatory Subunit 3B, GL. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | The PPP1R3B solution (1mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 0.4M urea and 10% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 85.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MGSMMAVDIE YRYNCMAPSL RQERFAFKIS PKPSKPLRPC IQLSSKNEAS GMVAPAVQEK KVKKRVSFAD NQGLALTMVK VFSEFDDPLD MPFNITELLD NIVSLTTAES ESFVLDFSQP SADYLDFRNR LQADHVCLEN CVLKDKAIAG TVKVQNLAFE KTVKIRMTFD TWKSYTDFPC QYVKDTYAGS DRDTFSFDIS LPEKIQSYER MEFAVYYECN GQTYWDSNRG KNYRIIRAEL KSTQGMTKPH SGPDLGISFD QFGSPRCSYG LFPEWPSYLG YEKLGPYY |
Protein Phosphatase 1, Regulatory Subunit 3B (PPP1R3B) is the catalytic subunit of the serine/theonine phosphatase, protein phosphatase-1. PPP1R3B, which is expressed both in liver and in skeletal muscle tissue, regulates glycogen synthesis in these tissues. PPP1R3B is involved in type 2 diabetes and maturity-onset diabetes of the young.
PPP1R3B Human Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 308 amino acids (1-285) and having a molecular mass of 35.1 kDa.PPP1R3B is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | PPP1R3B: Acts as a glycogen-targeting subunit for phosphatase PP1. Facilitates interaction of the PP1 with enzymes of the glycogen metabolism and regulates its activity. Suppresses the rate at which PP1 dephosphorylates (inactivates) glycogen phosphorylase and enhances the rate at which it activates glycogen synthase and therefore limits glycogen breakdown. Its activity is inhibited by PYGL, resulting in inhibition of the glycogen synthase and glycogen phosphorylase phosphatase activities of PP1. Dramatically increases basal and insulin-stimulated glycogen synthesis upon overexpression in hepatocytes. |
| UniProt Protein Details: | Protein type:Protein phosphatase, regulatory subunit Chromosomal Location of Human Ortholog: 8p23.1 Biological Process: regulation of glycogen catabolic process |
| NCBI Summary: | This gene encodes the catalytic subunit of the serine/theonine phosphatase, protein phosphatase-1. The encoded protein is expressed in liver and skeletal muscle tissue and may be involved in regulating glycogen synthesis in these tissues. This gene may be a involved in type 2 diabetes and maturity-onset diabetes of the young. Alternate splicing results in multiple transcript variants that encode the same protein.[provided by RefSeq, Jan 2011] |
| UniProt Code: | Q86XI6 |
| NCBI GenInfo Identifier: | 74727837 |
| NCBI Gene ID: | 79660 |
| NCBI Accession: | Q86XI6.1 |
| UniProt Secondary Accession: | Q86XI6,Q9H812, B3KTV3, |
| UniProt Related Accession: | Q86XI6 |
| Molecular Weight: | 32,695 Da |
| NCBI Full Name: | Protein phosphatase 1 regulatory subunit 3B |
| NCBI Synonym Full Names: | protein phosphatase 1 regulatory subunit 3B |
| NCBI Official Symbol: | PPP1R3B�� |
| NCBI Official Synonym Symbols: | GL; PTG; PPP1R4�� |
| NCBI Protein Information: | protein phosphatase 1 regulatory subunit 3B |
| UniProt Protein Name: | Protein phosphatase 1 regulatory subunit 3B |
| UniProt Synonym Protein Names: | Hepatic glycogen-targeting protein phosphatase 1 regulatory subunit GL; Protein phosphatase 1 regulatory subunit 4; PP1 subunit R4; Protein phosphatase 1 subunit GL; PTG |
| Protein Family: | Protein phosphatase 1 regulatory |
| UniProt Gene Name: | PPP1R3B�� |
| UniProt Entry Name: | PPR3B_HUMAN |
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