Human PPM1G Recombinant Protein (RPPB2159)
- SKU:
- RPPB2159
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- O15355
- Research Area:
- Enzymes
Description
| Product Name: | Human PPM1G Recombinant Protein |
| Product Code: | RPPB2159 |
| Size: | 50µg |
| Species: | Human |
| Target: | PPM1G |
| Synonyms: | Protein Phosphatase 1G, PP2CG, PPP2CG, MGC1675, MGC2870, PP2C GAMMA, EC 3.1.3.16, Protein phosphatase 2C isoform gamma, PP2C-gamma, Protein phosphatase magnesium-dependent 1 gamma, Protein phosphatase 1C, PPM1G, PPM1C. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | The PPM1G solution (1mg/ml) contains 25mM Tris pH-7.5, 1mM DTT, 1mM EDTA, 2mM b-ME and 20% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.�For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 95.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MEGKEEPGSD SGTTAVVALI RGKQLIVANA GDSRCVVSEA GKALDMSYDH KPEDEVELAR IKNAGGKVTM DGRVNGGLNL SRAIGDHFYK RNKNLPPEEQ MISALPDIKV LTLTDDHEFM VIACDGIWNV MSSQEVVDFI QSKISQRDEN GELRLLSSIV EELLDQCLAP DTSGDGTGCD NMTCIIICFK PRNTAELQPE SGKRKLEEVL STEGAEENGN SDKKKKAKRD |
PPM1G is part of the PP2C family of Ser/Thr protein phosphatases which are known to be negative regulators of cell stress response pathways. PPM1G is accountable for the dephosphorylation of Pre-mRNA splicing factors, an important factor for the formation of functional spliceosome. PPM1G regulates cell cycle progression. PPM1G mediates histone dephosphorylation/exchange in response to DNA damage or checkpoint recovery in higher eukaryotes. The degradation of p21/WAF1 induced by PPM1G is mediated in a proteasome-dependent manner. Protein phosphatase 1G regulates assembly and function of the beta-catenin degradation complex.
PPM1G Human Recombinant fused with His-tag at N-terminus produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 250 amino acids and having a molecular mass of 27 kDa.The PPM1G is purified by proprietary chromatographic techniques.
| UniProt Protein Function: | PPM1G: is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase is found to be responsible for the dephosphorylation of Pre-mRNA splicing factors, which is important for the formation of functional spliceosome. Studies of a similar gene in mice suggested a role of this phosphatase in regulating cell cycle progression. [provided by RefSeq, Apr 2010] |
| UniProt Protein Details: | Protein type:Spliceosome; Protein phosphatase, Ser/Thr (non-receptor); EC 3.1.3.16; Motility/polarity/chemotaxis Chromosomal Location of Human Ortholog: 2p23.3 Cellular Component: nucleoplasm; cytoplasm; nucleus Molecular Function:protein binding; metal ion binding; protein serine/threonine phosphatase activity Biological Process: protein amino acid dephosphorylation; cell cycle arrest |
| NCBI Summary: | The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase is found to be responsible for the dephosphorylation of Pre-mRNA splicing factors, which is important for the formation of functional spliceosome. Studies of a similar gene in mice suggested a role of this phosphatase in regulating cell cycle progression. [provided by RefSeq, Apr 2010] |
| UniProt Code: | O15355 |
| NCBI GenInfo Identifier: | 3122589 |
| NCBI Gene ID: | 5496 |
| NCBI Accession: | O15355.1 |
| UniProt Related Accession: | O15355 |
| Molecular Weight: | |
| NCBI Full Name: | Protein phosphatase 1G |
| NCBI Synonym Full Names: | protein phosphatase, Mg2+/Mn2+ dependent 1G |
| NCBI Official Symbol: | PPM1G�� |
| NCBI Official Synonym Symbols: | PP2CG; PPP2CG; PP2CGAMMA�� |
| NCBI Protein Information: | protein phosphatase 1G |
| UniProt Protein Name: | Protein phosphatase 1G |
| UniProt Synonym Protein Names: | Protein phosphatase 1C; Protein phosphatase 2C isoform gamma; PP2C-gamma; Protein phosphatase magnesium-dependent 1 gamma |
| Protein Family: | Protein phosphatase |
| UniProt Gene Name: | PPM1G�� |
| UniProt Entry Name: | PPM1G_HUMAN |
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