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Human PPIL1 Recombinant Protein (RPPB2154)

SKU:
RPPB2154
Product Type:
Recombinant Protein
Species:
Human
Uniprot:
Q9Y3C6
Research Area:
Enzymes
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Description

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Product Name:Human PPIL1 Recombinant Protein
Product Code:RPPB2154
Size:50µg
Species:Human
Target:PPIL1
Synonyms:Peptidyl-Prolyl Cis-Trans Isomerase-Like 1, PPIL-1, CYPL1, hCyPX, MGC678, PPIase, CGI-124, PPIL1.
Source:Escherichia Coli
Physical Appearance:Sterile filtered colorless solution.
Formulation:PPIL1 solution containing 20 mM Tris-HCl buffer (pH 8.0) and 20% glycerol
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.�For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 95.0% as determined by SDS-PAGE.
Amino Acid Sequence:MAAIPPDSWQ PPNVYLETSM GIIVLELYWK HAPKTCKNFA ELARRGYYNG TKFHRIIKDF MIQGGDPTGT GRGGASIYGK QFEDELHPDL KFTGAGILAM ANAGPDTNGS QFFVTLAPTQ WLDGKHTIFG RVCQGIGMVN RVGMVETNSQ DRPVDDVKII KAYPSGLEHH HHHH
Biological Activity:Specific activity is > 300 nmoles/min/mg, and is defined as the amount of enzyme that cleaves 1umole of suc-AAFP-pNA per minute at 25C in Tris-Hcl pH8.0 using chymotrypsin.

PPIL1 belongs to the cyclophilin family of peptidylprolyl isomerases (PPIases). The cyclophilins are a well conserved, ubiquitous family, members of which take an significant part in protein folding, immunosuppression by cyclosporin A, and infection of HIV-1 virions. PPIL1 protein increases the folding of proteins and catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. PPIL1 is involved in proliferation of cancer cells through modulation of phosphorylation of stathmin. PPIL1 is a novel molecular target for colon-cancer therapy.

PPIL1 Human Recombinant protein produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 174 amino acids (1-166) and having a molecular mass of 19.3 kDa. PPIL1 is fused to 8 amino acid His Tag at C-terminus and is purified by proprietary chromatographic techniques.

UniProt Protein Function:PPIL1: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. May be involved in pre-mRNA splicing. Belongs to the cyclophilin-type PPIase family. PPIL1 subfamily.
UniProt Protein Details:

Protein type:Isomerase; Spliceosome; EC 5.2.1.8; Cyclophilin

Chromosomal Location of Human Ortholog: 6p21.1

Molecular Function:peptidyl-prolyl cis-trans isomerase activity; protein binding

Biological Process: nuclear mRNA splicing, via spliceosome

NCBI Summary:This gene is a member of the cyclophilin family of peptidylprolyl isomerases (PPIases). The cyclophilins are a highly conserved, ubiquitous family, members of which play an important role in protein folding, immunosuppression by cyclosporin A, and infection of HIV-1 virions. Based on similarity to other PPIases, this protein could accelerate the folding of proteins and might catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. [provided by RefSeq, Jul 2008]
UniProt Code:Q9Y3C6
NCBI GenInfo Identifier:20177874
NCBI Gene ID:51645
NCBI Accession:Q9Y3C6.1
UniProt Secondary Accession:Q9Y3C6,O15001, Q5TDC9,
UniProt Related Accession:Q9Y3C6
Molecular Weight:18,237 Da
NCBI Full Name:Peptidyl-prolyl cis-trans isomerase-like 1
NCBI Synonym Full Names:peptidylprolyl isomerase like 1
NCBI Official Symbol:PPIL1��
NCBI Official Synonym Symbols:CYPL1; hCyPX; PPIase; CGI-124��
NCBI Protein Information:peptidyl-prolyl cis-trans isomerase-like 1
UniProt Protein Name:Peptidyl-prolyl cis-trans isomerase-like 1
UniProt Synonym Protein Names:Rotamase PPIL1
Protein Family:Peptidyl-prolyl cis-trans isomerase
UniProt Gene Name:PPIL1��
UniProt Entry Name:PPIL1_HUMAN

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