Human PNRC2 Recombinant Protein (RPPB4267)
- SKU:
- RPPB4267
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- Q9NPJ4
Description
| Product Name: | Human PNRC2 Recombinant Protein |
| Product Code: | RPPB4267 |
| Size: | 20µg |
| Species: | Human |
| Target: | PNRC2 |
| Synonyms: | Proline-rich nuclear receptor coactivator 2, PNRC2. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered clear solution. |
| Formulation: | The PNRC2 solution (1mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 0.4M UREA and 10% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 90% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MGSMGGGERY NIPAPQSRNV SKNQQQLNRQ KTKEQNSQMK IVHKKKERGH GYNSSAAAWQ AMQNGGKNKN FPNNQSWNSS LSGPRLLFKS QANQNYAGAK FSEPPSPSVL PKPPSHWVPV SFNPSDKEIM TFQLKTLLKV QV |
Proline-Rich Nuclear Receptor Coactivator 2 (PNRC2) takes part in controlling the energy balance between energy storage and energy expenditure. PNRC2 is involved in nonsense-mediated mRNA decay (NMD) by operating as a bridge between the mRNA decapping complex and the NMD machinery. PNRC2 is needed for UPF1/RENT1 localization to the P-body and also plays a role as a nuclear receptor coactivator.
PNRC2 Human Recombinant produced in E. coli is a single polypeptide chain containing 162 amino acids (1-139) and having a molecular mass of 18kDa. PNRC2 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | PNRC2: Involved in nonsense-mediated mRNA decay (NMD) by acting as a bridge between the mRNA decapping complex and the NMD machinery. May act by targeting the NMD machinery to the P-body and recruiting the decapping machinery to aberrant mRNAs. Required for UPF1/RENT1 localization to the P-body. Also acts as a nuclear receptor coactivator. May play a role in controlling the energy balance between energy storage and energy expenditure. Belongs to the PNRC family. PNRC2 subfamily. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Transcription regulation; Nuclear receptor co-regulator Chromosomal Location of Human Ortholog: 1p36.11 Cellular Component: nucleus Molecular Function:protein binding Biological Process: deadenylation-independent decapping; mRNA catabolic process, nonsense-mediated decay; regulation of transcription, DNA-dependent; transcription, DNA-dependent |
| UniProt Code: | Q9NPJ4 |
| NCBI GenInfo Identifier: | 8923295 |
| NCBI Gene ID: | 55629 |
| NCBI Accession: | NP_060231.1 |
| UniProt Secondary Accession: | Q9NPJ4,B4DU72, |
| UniProt Related Accession: | Q9NPJ4 |
| Molecular Weight: | 13,471 Da |
| NCBI Full Name: | proline-rich nuclear receptor coactivator 2 |
| NCBI Synonym Full Names: | proline rich nuclear receptor coactivator 2 |
| NCBI Official Symbol: | PNRC2�� |
| NCBI Protein Information: | proline-rich nuclear receptor coactivator 2 |
| UniProt Protein Name: | Proline-rich nuclear receptor coactivator 2 |
| Protein Family: | Proline-rich nuclear receptor coactivator |
| UniProt Gene Name: | PNRC2�� |
| UniProt Entry Name: | PNRC2_HUMAN |
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