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Human PLGF1 Recombinant Protein (RPPB0861)

SKU:
RPPB0861
Product Type:
Recombinant Protein
Species:
Human
Uniprot:
P49763
Research Area:
Growth Factors & Cytokines
$371
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Description

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Product Name:Human PLGF1 Recombinant Protein
Product Code:RPPB0861
Size:10µg
Species:Human
Target:PLGF1
Synonyms:PIGF, PGF, PLGF-1.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered White lyophilized (freeze-dried) powder.
Formulation:Lyophilized from a 0.2?m filtered concentrated solution in 10mM Sodium Phosphate pH 7.5.
Solubility:It is recommended to reconstitute the lyophilized Placental Growth Factor-1 in sterile 18M?-cm H2O not less than 100�g/ml, which can then be further diluted to other aqueous solutions.
Stability:Lyophilized PLGF1 although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution Placental Growth Factor-1 should be stored at 4°C between 2-7 days and for future use below -18°C.Please prevent freeze-thaw cycles.
Purity:Greater than 95.0% as determined by:(a) Analysis by RP-HPLC.(b) Analysis by SDS-PAGE.
Amino Acid Sequence:MLPAVPPQQW ALSAGNGSSE VEVVPFQEVW GRSYCRALER LVDVVSEYPS EVEHMFSPSC VSLLRCTGCC GDENLHCVPV ETANVTMQLL KIRSGDRPSY VELTFSQHVR CECRPLREKM KPERCGDAVP RR
Biological Activity:Determined by its ability to chemoattract human monocytes of using a concentration range of 1.0-10.0 ng/ml.

PLGF is a growth factor active in angiogenesis, and endothelial cell growth, stimulating their proliferation and migration. It binds to receptor vegfr-1/flt1.

Placental Growth Factor-1 Human Recombinant produced in E.Coli is a non-glycosylated, disulfide-linked homodimer consisting of 2x132 amino acid polypeptide chains, having a total molecular mass of approximately 29.7kDa.PLGF1 is purified by proprietary chromatographic techniques.

UniProt Protein Function:PGF: Growth factor active in angiogenesis and endothelial cell growth, stimulating their proliferation and migration. It binds to the receptor FLT1/VEGFR-1. Isoform PlGF-2 binds NRP1/neuropilin-1 and NRP2/neuropilin-2 in a heparin-dependent manner. Also promotes cell tumor growth. Belongs to the PDGF/VEGF growth factor family. 3 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 14q24.3

Cellular Component: extracellular space; membrane; extracellular region

Molecular Function:heparin binding; protein binding; protein homodimerization activity; growth factor activity; protein heterodimerization activity

Biological Process: response to drug; organ regeneration; female pregnancy; signal transduction; cellular response to hormone stimulus; positive regulation of angiogenesis; cell-cell signaling; ureteric bud branching; positive regulation of cell division; positive regulation of cell proliferation; response to hypoxia; positive regulation of endothelial cell proliferation; sprouting angiogenesis; vascular endothelial growth factor receptor signaling pathway; cell differentiation

NCBI Summary:This gene encodes a growth factor found in placenta which is homologous to vascular endothelial growth factor. Alternatively spliced transcripts encoding different isoforms have been found for this gene.[provided by RefSeq, Jun 2011]
UniProt Code:P49763
NCBI GenInfo Identifier:17380553
NCBI Gene ID:5228
NCBI Accession:P49763.2
UniProt Secondary Accession:P49763,Q07101, Q9BV78, Q9Y6S8,
UniProt Related Accession:P49763
Molecular Weight:19,338 Da
NCBI Full Name:Placenta growth factor
NCBI Synonym Full Names:placental growth factor
NCBI Official Symbol:PGF��
NCBI Official Synonym Symbols:PGFL; PLGF; PlGF-2; D12S1900; SHGC-10760��
NCBI Protein Information:placenta growth factor; placental growth factor, vascular endothelial growth factor-related protein
UniProt Protein Name:Placenta growth factor
Protein Family:Placenta growth factor
UniProt Gene Name:PGF��
UniProt Entry Name:PLGF_HUMAN

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