Human PLGF1 Recombinant Protein (RPPB0859)
- SKU:
- RPPB0859
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- P49763
- Research Area:
- Growth Factors & Cytokines
Description
| Product Name: | Human PLGF1 Recombinant Protein |
| Product Code: | RPPB0859 |
| Size: | 10µg |
| Species: | Human |
| Target: | PLGF1 |
| Synonyms: | PIGF, PGF, PLGF-1. |
| Source: | Insect Cells |
| Physical Appearance: | Sterile Filtered White lyophilized (freeze-dried) powder. |
| Formulation: | Lyophilized from a concentrated (1mg/ml) solution containing 50mM acetic acid. |
| Solubility: | It is recommended to reconstitute the lyophilized Placenta Growth Factor 1 in sterile 0.1M acetic acid not less than 100�g/ml, which can then be further diluted to other aqueous solutions. |
| Stability: | Lyophilized Placenta Growth Factor 1 although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution PLGF1 should be stored at 4°C between 2-7 days and for future use below -18°C.Please prevent freeze-thaw cycles. |
| Purity: | Greater than 95.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | The sequence of the first five N-terminal amino acids was determined and was found to be Met-Leu-Pro-Ala-Val |
| Biological Activity: | The ED50 as determined by its ability to bind to immobilized rh-sFlt-1 in a functional ELISA. PlGF-1 human Recombinant can bind to immobilized rh-sFlt-1 (100ng/well) with a linear range at 0.5-10ng/ml, corresponding to a Specific Activity of 1x105-2x106units/mg. |
PLGF is a growth factor active in angiogenesis, and endothelial cell growth, stimulating their proliferation and migration. It binds to receptor vegfr-1/flt1.
Placenta Growth Factor-1 Human Recombinant produced in insect cells is a homodimer, glycosylated polypeptide chain containing 2 x 131 amino acids and having a total molecular mass of approximately 34 kDa. The PLGF-1 is purified by proprietary chromatographic techniques.
| UniProt Protein Function: | PGF: Growth factor active in angiogenesis and endothelial cell growth, stimulating their proliferation and migration. It binds to the receptor FLT1/VEGFR-1. Isoform PlGF-2 binds NRP1/neuropilin-1 and NRP2/neuropilin-2 in a heparin-dependent manner. Also promotes cell tumor growth. Belongs to the PDGF/VEGF growth factor family. 3 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Secreted; Secreted, signal peptide Chromosomal Location of Human Ortholog: 14q24.3 Cellular Component: extracellular space; membrane; extracellular region Molecular Function:heparin binding; protein binding; protein homodimerization activity; growth factor activity; protein heterodimerization activity Biological Process: response to drug; organ regeneration; female pregnancy; signal transduction; cellular response to hormone stimulus; positive regulation of angiogenesis; cell-cell signaling; ureteric bud branching; positive regulation of cell division; positive regulation of cell proliferation; response to hypoxia; positive regulation of endothelial cell proliferation; sprouting angiogenesis; vascular endothelial growth factor receptor signaling pathway; cell differentiation |
| NCBI Summary: | This gene encodes a growth factor found in placenta which is homologous to vascular endothelial growth factor. Alternatively spliced transcripts encoding different isoforms have been found for this gene.[provided by RefSeq, Jun 2011] |
| UniProt Code: | P49763 |
| NCBI GenInfo Identifier: | 17380553 |
| NCBI Gene ID: | 5228 |
| NCBI Accession: | P49763.2 |
| UniProt Secondary Accession: | P49763,Q07101, Q9BV78, Q9Y6S8, |
| UniProt Related Accession: | P49763 |
| Molecular Weight: | 19,338 Da |
| NCBI Full Name: | Placenta growth factor |
| NCBI Synonym Full Names: | placental growth factor |
| NCBI Official Symbol: | PGF�� |
| NCBI Official Synonym Symbols: | PGFL; PLGF; PlGF-2; D12S1900; SHGC-10760�� |
| NCBI Protein Information: | placenta growth factor; placental growth factor, vascular endothelial growth factor-related protein |
| UniProt Protein Name: | Placenta growth factor |
| Protein Family: | Placenta growth factor |
| UniProt Gene Name: | PGF�� |
| UniProt Entry Name: | PLGF_HUMAN |
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