Human PLGF Recombinant Protein (RPPB0862)
- SKU:
- RPPB0862
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- P49763
- Research Area:
- Growth Factors & Cytokines
Description
Product Name: | Human PLGF Recombinant Protein |
Product Code: | RPPB0862 |
Size: | 10µg |
Species: | Human |
Target: | PLGF |
Synonyms: | PIGF, PGF, PLGF-1. |
Source: | Escherichia Coli |
Physical Appearance: | Filtered White lyophilized (freeze-dried) powder. |
Formulation: | PLGF1 filtered (0.4 �m) and lyophilized from 0.5mg/ml in PBS and 5% w/v trehalose, pH 7.4. |
Solubility: | It is recommended to add 200�l deionized water to prepare a working stock solution of approximately 0.5mg/ml and let the lyophilized pellet dissolve completely. PLGF1 is not sterile! Please filter the product by an appropriate sterile filter before using it in the cell culture. |
Stability: | Store lyophilized protein at -20°C. Aliquot the product after reconstitution to avoid repeated freezing/thawing cycles. Reconstituted protein can be stored at 4°C for a limited period of time; it does not show any change after two weeks at 4°C. |
Purity: | Greater than 95.0% as determined by SDS-PAGE. |
Amino Acid Sequence: | MKHHHHHHAS LPAVPPQQWA LSAGNGSSEV EVVPFQEVWG RSYCRALERL VDVVSEYPSE VEHMFSPSCV SLLRCTGCCG DENLHCVPVE TANVTMQLLK IRSGDRPSYV ELTFSQHVRC ECR |
PLGF is a growth factor active in angiogenesis, and endothelial cell growth, stimulating their proliferation and migration. It binds to receptor vegfr-1/flt1.
PLGF1 Human Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain (a.a 19-131) containing 123 amino acids including a 10 a.a N-terminal His tag. The total molecular mass is 13.8kDa (calculated).�
UniProt Protein Function: | PGF: Growth factor active in angiogenesis and endothelial cell growth, stimulating their proliferation and migration. It binds to the receptor FLT1/VEGFR-1. Isoform PlGF-2 binds NRP1/neuropilin-1 and NRP2/neuropilin-2 in a heparin-dependent manner. Also promotes cell tumor growth. Belongs to the PDGF/VEGF growth factor family. 3 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Secreted; Secreted, signal peptide Chromosomal Location of Human Ortholog: 14q24.3 Cellular Component: extracellular space; membrane; extracellular region Molecular Function:heparin binding; protein binding; protein homodimerization activity; growth factor activity; protein heterodimerization activity Biological Process: response to drug; organ regeneration; female pregnancy; signal transduction; cellular response to hormone stimulus; positive regulation of angiogenesis; cell-cell signaling; ureteric bud branching; positive regulation of cell division; positive regulation of cell proliferation; response to hypoxia; positive regulation of endothelial cell proliferation; sprouting angiogenesis; vascular endothelial growth factor receptor signaling pathway; cell differentiation |
NCBI Summary: | This gene encodes a growth factor found in placenta which is homologous to vascular endothelial growth factor. Alternatively spliced transcripts encoding different isoforms have been found for this gene.[provided by RefSeq, Jun 2011] |
UniProt Code: | P49763 |
NCBI GenInfo Identifier: | 17380553 |
NCBI Gene ID: | 5228 |
NCBI Accession: | P49763.2 |
UniProt Secondary Accession: | P49763,Q07101, Q9BV78, Q9Y6S8, |
UniProt Related Accession: | P49763 |
Molecular Weight: | 19,338 Da |
NCBI Full Name: | Placenta growth factor |
NCBI Synonym Full Names: | placental growth factor |
NCBI Official Symbol: | PGF�� |
NCBI Official Synonym Symbols: | PGFL; PLGF; PlGF-2; D12S1900; SHGC-10760�� |
NCBI Protein Information: | placenta growth factor; placental growth factor, vascular endothelial growth factor-related protein |
UniProt Protein Name: | Placenta growth factor |
Protein Family: | Placenta growth factor |
UniProt Gene Name: | PGF�� |
UniProt Entry Name: | PLGF_HUMAN |