Human PKIB Recombinant Protein (RPPB2619)
- SKU:
- RPPB2619
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- Q9C010
- Research Area:
- Enzymes
Description
| Product Name: | Human PKIB Recombinant Protein |
| Product Code: | RPPB2619 |
| Size: | 25µg |
| Species: | Human |
| Target: | PKIB |
| Synonyms: | cAMP-dependent protein kinase inhibitor beta, PKI-beta, PKIB, PRKACN2, FLJ23817. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile filtered colorless solution. |
| Formulation: | PKIB solution (1mg/ml) 20mM Tris-HCl buffer (pH8.0), 20% glycerol, 0.1M NaCl and 1mM DTT. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 95.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MRTDSSKMTD VESGVANFAS SARAGRRNAL PDIQSSAATD GTSDLPLKLE ALSVKEDAKE KDEKTTQDQL EKPQNEEK |
cAMP-dependent protein kinase inhibitor beta (PKIB) belongs to the cAMP-dependent protein kinase inhibitor family. PKIB may interact with the catalytic subunit of cAMP-dependent protein kinase and function as a competitive inhibitor.
PKIB Human Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 98 amino acids (1-78) and having a molecular mass of 10.6kDa (Molecular size on SDS-PAGE will appear higher). PKIB is fused to a 20 aa His-Tag at N-terminus and purified by proprietary chromatographic techniques.
| UniProt Protein Function: | PKIB: Extremely potent competitive inhibitor of cAMP-dependent protein kinase activity, this protein interacts with the catalytic subunit of the enzyme after the cAMP-induced dissociation of its regulatory chains. Belongs to the PKI family. |
| UniProt Protein Details: | Protein type:Protein kinase, regulatory subunit; Inhibitor Chromosomal Location of Human Ortholog: 6q22.31 Cellular Component: cytoplasm; nucleus Molecular Function:cAMP-dependent protein kinase inhibitor activity |
| NCBI Summary: | This gene encodes a member of the cAMP-dependent protein kinase inhibitor family. The encoded protein may play a role in the protein kinase A (PKA) pathway by interacting with the catalytic subunit of PKA, and overexpression of this gene may play a role in prostate cancer. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jul 2012] |
| UniProt Code: | Q9C010 |
| NCBI GenInfo Identifier: | 17378640 |
| NCBI Gene ID: | 5570 |
| NCBI Accession: | Q9C010.1 |
| UniProt Secondary Accession: | Q9C010,Q567T9, Q5T0Z7, B2RCK2, |
| UniProt Related Accession: | Q9C010 |
| Molecular Weight: | 9,237 Da |
| NCBI Full Name: | cAMP-dependent protein kinase inhibitor beta |
| NCBI Synonym Full Names: | protein kinase (cAMP-dependent, catalytic) inhibitor beta |
| NCBI Official Symbol: | PKIB�� |
| NCBI Official Synonym Symbols: | PRKACN2�� |
| NCBI Protein Information: | cAMP-dependent protein kinase inhibitor beta; PKI-beta; cAMP-dependent protein kinase inhibitor 2 |
| UniProt Protein Name: | cAMP-dependent protein kinase inhibitor beta |
| Protein Family: | cAMP-dependent protein kinase |
| UniProt Gene Name: | PKIB�� |
| UniProt Entry Name: | IPKB_HUMAN |
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