Human PFN1 Recombinant Protein (RPPB4233)
- SKU:
- RPPB4233
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- P07737
Description
| Product Name: | Human PFN1 Recombinant Protein |
| Product Code: | RPPB4233 |
| Size: | 50µg |
| Species: | Human |
| Target: | PFN1 |
| Synonyms: | Profilin-1, Profilin I, PFN1. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | The PFN1 protein solution contains 20mM Tris-HCl buffer (pH8.0) and 10% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 95.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MAGWNAYIDN LMADGTCQDA AIVGYKDSPS VWAAVPGKTF VNITPAEVGV LVGKDRSSFY VNGLTLGGQK CSVIRDSLLQ DGEFSMDLRT KSTGGAPTFN VTVTKTDKTL VLLMGKEGVH GGLINKKCYE MASHLRRSQY |
Profilin1 (PFN1) is a ubiquitous actin monomer-binding protein which is a member of the profilin family. PFN1 significantly boosts skin wound healing in-vitro and in-vivo which may be mediated by purinergic receptors. PFN1 is also active in endothelial cell migration and vessel sprouting. PFN1 is thought to control actin polymerization in response to extracellular signals. PFN1 binds to actin and affects the formation of the cytoskeleton. In addition, PFN1 has an important role in the regulation of epithelial cell-cell adhesion. At high concentrations, profilin averts the polymerization of actin, while at low concentrations it enhances the polymerization. PFN1 gene deletion is linked to Miller-Dieker syndrome.
PFN1 Human Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 140 amino acids (1-140 a.a.) and having a molecular mass of 15kDa.The PFN1 is purified by proprietary chromatographic techniques.
| UniProt Protein Function: | profilin 1: a ubiquitous actin monomer-binding protein belonging to the profilin family. At high concentrations, profilin 1 prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG. Deletion of this gene is associated with Miller-Dieker syndrome. |
| UniProt Protein Details: | Protein type:Cytoskeletal; Motility/polarity/chemotaxis; Actin-binding Chromosomal Location of Human Ortholog: 17p13.3 Cellular Component: cell cortex; cytoplasm; cytosol; focal adhesion; membrane; nucleus Molecular Function:actin binding; actin monomer binding; adenyl-nucleotide exchange factor activity; phosphatidylinositol-4,5-bisphosphate binding; protein binding Biological Process: negative regulation of actin filament bundle formation; negative regulation of actin filament polymerization; negative regulation of stress fiber formation; positive regulation of actin filament bundle formation; positive regulation of actin filament polymerization; positive regulation of ATPase activity; protein stabilization; Wnt receptor signaling pathway, planar cell polarity pathway Disease: Amyotrophic Lateral Sclerosis 18 |
| NCBI Summary: | This gene encodes a member of the profilin family of small actin-binding proteins. The encoded protein plays an important role in actin dynamics by regulating actin polymerization in response to extracellular signals. Deletion of this gene is associated with Miller-Dieker syndrome, and the encoded protein may also play a role in Huntington disease. Multiple pseudogenes of this gene are located on chromosome 1. [provided by RefSeq, Jul 2012] |
| UniProt Code: | P07737 |
| NCBI GenInfo Identifier: | 130979 |
| NCBI Gene ID: | 5216 |
| NCBI Accession: | P07737.2 |
| UniProt Secondary Accession: | P07737,Q53Y44, |
| UniProt Related Accession: | P07737 |
| Molecular Weight: | 15,054 Da |
| NCBI Full Name: | Profilin-1 |
| NCBI Synonym Full Names: | profilin 1 |
| NCBI Official Symbol: | PFN1�� |
| NCBI Official Synonym Symbols: | ALS18�� |
| NCBI Protein Information: | profilin-1 |
| UniProt Protein Name: | Profilin-1 |
| UniProt Synonym Protein Names: | Epididymis tissue protein Li 184a; Profilin I |
| UniProt Gene Name: | PFN1�� |
| UniProt Entry Name: | PROF1_HUMAN |
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