Human PECI Recombinant Protein (RPPB2090)
- SKU:
- RPPB2090
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- O75521
- Research Area:
- Enzymes
Description
| Product Name: | Human PECI Recombinant Protein |
| Product Code: | RPPB2090 |
| Size: | 25µg |
| Species: | Human |
| Target: | PECI |
| Synonyms: | EC 5.3.3.8, ACBD2, DRS1, HCA88, PECI, Peroxisomal 3,2-trans-enoyl-CoA isomerase, Dodecenoyl-CoA isomerase, Delta(3),delta(2)-enoyl-CoA isomerase, D3,D2-enoyl-CoA isomerase, Diazepam-binding inhibitor-related protein 1, DBI-related protein 1, DRS-1, Hepatocellular carcinoma-associated antigen 88, Renal carcinoma antigen NY-REN-1, KIAA0536, dJ1013A10. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile filtered colorless solution. |
| Formulation: | PECI Human solution (1mg/ml) containing 20mM Tris-HCl, pH-8 and 10% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.�For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 95.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MNRTAMRASQ KDFENSMNQV KLLKKDPGNE VKLKLYALYK QATEGPCNMP KPGVFDLINK AKWDAWNALG SLPKEAARQN YVDLVSSLSP SLESSSQVEP GTDRKSTGFE TLVVTSEDGI TKIMFNRPKK KNAINTEMYH EIMRALKAAS KDDSIITVLT GNGDYYSSGN DLTNFTDIPP GGVEEKAKNN AVLLREFVGC FIDFPKPLIA VVNGPAVGIS VTLLGLFDAV YASDRATFHT PFSHLGQSPE GCSSYTFPKI MSPAKATEML IFGKKLTAGE ACAQGLVTEV FPDSTFQKEV WTRLKAFAKL PPNALRISKE VIRKREREKL HAVNAEECNV LQGRWLSDEC TNAVVNFLSR KSKL |
PECI is an enzyme that localized to the peroxisomal matrix and encloses one ACB (acyl-CoA-binding) domain. PECI is expressed abundantly in liver, heart and skeletal muscle. PECI functions to catalyze the isomerization of both 3-cis and 3-trans double bonds into the 2-trans form in an array of enoyl-CoA species. PECI takes part in the beta-oxidation of unsaturated fatty acids.
PECI Recombinant Human produced in E.Coli is a single, non-glycosylated polypeptide chain containing 384 amino acids (1-364 a.a.) and having a molecular mass of 42.3 kDa. The PECI is fused to 20 amino acid His-Tag at N-terminus and purified by proprietary chromatographic techniques.
| UniProt Protein Function: | PECI: Able to isomerize both 3-cis and 3-trans double bonds into the 2-trans form in a range of enoyl-CoA species. Has a preference for 3-trans substrates. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Isomerase; EC 5.3.3.8; Lipid Metabolism - fatty acid Chromosomal Location of Human Ortholog: 6p24.3 Cellular Component: intracellular membrane-bound organelle; membrane; mitochondrion; nucleoplasm; peroxisomal matrix Molecular Function:dodecenoyl-CoA delta-isomerase activity; receptor binding Biological Process: cellular lipid metabolic process |
| NCBI Summary: | This gene encodes a member of the hydratase/isomerase superfamily. The protein encoded is a key mitochondrial enzyme involved in beta-oxidation of unsaturated fatty acids. It catalyzes the transformation of 3-cis and 3-trans-enoyl-CoA esters arising during the stepwise degradation of cis-, mono-, and polyunsaturated fatty acids to the 2-trans-enoyl-CoA intermediates. Alternatively spliced transcript variants have been described. [provided by RefSeq, Aug 2011] |
| UniProt Code: | O75521 |
| NCBI GenInfo Identifier: | 257051079 |
| NCBI Gene ID: | 10455 |
| NCBI Accession: | O75521.4 |
| UniProt Secondary Accession: | O75521,Q5JYK5, Q5JYK7, Q7L124, Q8N0X0, Q9BUE9, Q9H0T9 Q9NQH1, Q9NYH7, Q9UN55, |
| UniProt Related Accession: | O75521 |
| Molecular Weight: | 39,609 Da |
| NCBI Full Name: | Enoyl-CoA delta isomerase 2, mitochondrial |
| NCBI Synonym Full Names: | enoyl-CoA delta isomerase 2 |
| NCBI Official Symbol: | ECI2�� |
| NCBI Official Synonym Symbols: | DRS1; PECI; ACBD2; DRS-1; HCA88; dJ1013A10.3�� |
| NCBI Protein Information: | enoyl-CoA delta isomerase 2, mitochondrial |
| UniProt Protein Name: | Enoyl-CoA delta isomerase 2, mitochondrial |
| UniProt Synonym Protein Names: | DRS-1; Delta(3),delta(2)-enoyl-CoA isomerase; D3,D2-enoyl-CoA isomerase; Diazepam-binding inhibitor-related protein 1; DBI-related protein 1; Dodecenoyl-CoA isomerase; Hepatocellular carcinoma-associated antigen 88; Peroxisomal 3,2-trans-enoyl-CoA isomerase; pECI; Renal carcinoma antigen NY-REN-1 |
| Protein Family: | Enoyl-CoA delta isomerase |
| UniProt Gene Name: | ECI2�� |
| UniProt Entry Name: | ECI2_HUMAN |
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