Human PDGFD Recombinant Protein (RPPB0843)
- SKU:
- RPPB0843
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- Q9GZP0
- Research Area:
- Growth Factors & Cytokines
Description
| Product Name: | Human PDGFD Recombinant Protein |
| Product Code: | RPPB0843 |
| Size: | 20µg |
| Species: | Human |
| Target: | PDGFD |
| Synonyms: | Platelet Derived Growth Factor D, Spinal Cord-Derived Growth Factor B, Iris-Expressed Growth Factor, SCDGF-B, IEGF, PDGF-D, MSTP036. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | The PDGFD solution (1mg/1ml) contains 20mM Tris-HCl buffer (pH 8.0), 0.4M Urea and 10% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 90% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MGSHMSYHDR KSKVDLDRLN DDAKRYSCTP RNYSVNIREE LKLANVVFFP RCLLVQRCGG NCGCGTVNWR SCTCNSGKTV KKYHEVLQFE PGHIKRRGRA KTMALVDIQL DHHERCDCIC SSRPPR |
Platelet-derived growth factor D (PDGFD) belongs to the platelet-derived growth factor family. PDGFD gene product only forms homodimers and, thus, does not dimerize with the other 3 family members. PDGFD has an imperative role in wound healing. PDGFD induces macrophage recruitment, increased interstitial pressure, and blood vessel maturation during angiogenesis. PDGFD initiates events which lead to a mesangial proliferative glomerulonephritis, including influx of monocytes and macrophages and production of extracellular matrix. The 4 members of the PDGF family are mitogenic factors for cells of mesenchymal origin and are distinguished by a core motif of eight cysteines, 7 of which are found in this factor. PDGFD differs from alpha and beta members of this family by having an odd N-terminal domain, the CUB domain.
PDGFD Human Recombinant produced in E. coli is a single polypeptide chain containing 146 amino acids (250-370) and having a molecular mass of 16.6 kDa.PDGFD is fused to a 25 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | PDGFD: Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen for cells of mesenchymal origin. Plays an important role in wound healing. Induces macrophage recruitment, increased interstitial pressure, and blood vessel maturation during angiogenesis. Can initiate events that lead to a mesangial proliferative glomerulonephritis, including influx of monocytes and macrophages and production of extracellular matrix. Belongs to the PDGF/VEGF growth factor family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Secreted; Secreted, signal peptide; Oncoprotein Chromosomal Location of Human Ortholog: 11q22.3 Cellular Component: Golgi membrane; endoplasmic reticulum lumen; extracellular region Molecular Function:growth factor activity; platelet-derived growth factor receptor binding Biological Process: multicellular organismal development; positive regulation of cell division; platelet-derived growth factor receptor signaling pathway; regulation of peptidyl-tyrosine phosphorylation |
| NCBI Summary: | The protein encoded by this gene is a member of the platelet-derived growth factor family. The four members of this family are mitogenic factors for cells of mesenchymal origin and are characterized by a core motif of eight cysteines, seven of which are found in this factor. This gene product only forms homodimers and, therefore, does not dimerize with the other three family members. It differs from alpha and beta members of this family in having an unusual N-terminal domain, the CUB domain. Two splice variants have been identified for this gene. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q9GZP0 |
| NCBI GenInfo Identifier: | 13376808 |
| NCBI Gene ID: | 80310 |
| NCBI Accession: | NP_079484.1 |
| UniProt Secondary Accession: | Q9GZP0,Q9BWV5, A8K9T6, |
| UniProt Related Accession: | Q9GZP0 |
| Molecular Weight: | |
| NCBI Full Name: | platelet-derived growth factor D isoform 1 |
| NCBI Synonym Full Names: | platelet derived growth factor D |
| NCBI Official Symbol: | PDGFD�� |
| NCBI Official Synonym Symbols: | IEGF; SCDGFB; MSTP036; SCDGF-B�� |
| NCBI Protein Information: | platelet-derived growth factor D |
| UniProt Protein Name: | Platelet-derived growth factor D |
| UniProt Synonym Protein Names: | Iris-expressed growth factor; Spinal cord-derived growth factor B; SCDGF-B |
| Protein Family: | Platelet-derived growth factor |
| UniProt Gene Name: | PDGFD�� |
| UniProt Entry Name: | PDGFD_HUMAN |
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