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Human PDCD6 Recombinant Protein (RPPB4211)

SKU:
RPPB4211
Product Type:
Recombinant Protein
Species:
Human
Uniprot:
O75340
€309
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Description

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Product Name:Human PDCD6 Recombinant Protein
Product Code:RPPB4211
Size:10µg
Species:Human
Target:PDCD6
Synonyms:Programmed cell death 6, ALG-2, PEF1B, Apoptosis-linked gene 2 protein, Probable calcium-binding protein ALG-2, FLJ46208, MGC111017, MGC119050, MGC9123.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered clear solution.
Formulation:The PDCD6 protein solution (0.5mg/1ml) is formulated in 10mM sodium citrate (pH 3.5) and 40% glycerol.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.�For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 95% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH�SSGLVPRGSH MAAYSYRPGP GAGPGPAAGA ALPDQSFLWN VFQRVDKDRS GVISDTELQQ ALSNGTWTPF NPVTVRSIIS MFDRENKAGV NFSEFTGVWK YITDWQNVFR TYDRDNSGMI DKNELKQALS GFGYRLSDQF HDILIRKFDR QGRGQIAFDD FIQGCIVLQR LTDIFRRYDT DQDGWIQVSY EQYLSMVFSI V

PDCD6 is a calcium-binding protein and is a member of the penta-EF-hand protein family. Calcium binding is vital for homodimerization and for conformational changes essential for binding to other protein partners. PDCD6 takes part in T cell receptor-, Fas-, and glucocorticoid-induced programmed cell death. However, tests showed that in mice deficient for PDCD6, apoptosis was not blocked which suggests that PDCD6 is functionally redundant.

PDCD6 produced in E.Coli is a single, non-glycosylated polypeptide chain containing 211 amino acids (1-191a.a.) and having a molecular mass of 24.0 kDa. PDCD6 is fused to a 20 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

UniProt Protein Function:PDCD6: Calcium-binding protein required for T-cell receptor-, Fas-, and glucocorticoid-induced cell death. May mediate Ca(2+)- regulated signals along the death pathway. Calcium-dependent adapter necessary for the association between PDCD6IP and TSG101. Interaction with DAPK1 can accelerate apoptotic cell death by increasing caspase-3 activity.
UniProt Protein Details:

Chromosomal Location of Human Ortholog: 5p15.33

Cellular Component: endoplasmic reticulum membrane; nuclear membrane; endoplasmic reticulum; cytoplasm; cytoplasmic vesicle; nucleus; endosome

Molecular Function:protein dimerization activity; protein binding; protein homodimerization activity; protein anchor; calcium-dependent cysteine-type endopeptidase activity; calcium ion binding; calcium-dependent protein binding; molecular adaptor activity

Biological Process: caspase activation; intracellular protein transport; negative regulation of TOR signaling pathway; positive regulation of angiogenesis; negative regulation of protein kinase B signaling cascade; negative regulation of vascular endothelial growth factor receptor signaling pathway; positive regulation of caspase activity; positive regulation of endothelial cell proliferation; angiogenesis; proteolysis; response to calcium ion

NCBI Summary:This gene encodes a calcium-binding protein belonging to the penta-EF-hand protein family. Calcium binding is important for homodimerization and for conformational changes required for binding to other protein partners. This gene product participates in T cell receptor-, Fas-, and glucocorticoid-induced programmed cell death. In mice deficient for this gene product, however, apoptosis was not blocked suggesting this gene product is functionally redundant. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is also located on the short arm of chromosome 5. [provided by RefSeq, May 2012]
UniProt Code:O75340
NCBI GenInfo Identifier:12230420
NCBI Gene ID:10016
NCBI Accession:O75340.1
UniProt Secondary Accession:O75340,Q2YDC2, Q5TZS0, B2RD16, E7ESR3,
UniProt Related Accession:O75340
Molecular Weight:191
NCBI Full Name:Programmed cell death protein 6
NCBI Synonym Full Names:programmed cell death 6
NCBI Official Symbol:PDCD6��
NCBI Official Synonym Symbols:ALG2; ALG-2; PEF1B��
NCBI Protein Information:programmed cell death protein 6; apoptosis-linked gene 2 protein; probable calcium-binding protein ALG-2
UniProt Protein Name:Programmed cell death protein 6
UniProt Synonym Protein Names:Apoptosis-linked gene 2 protein; Probable calcium-binding protein ALG-2
Protein Family:Programmed cell death protein
UniProt Gene Name:PDCD6��
UniProt Entry Name:PDCD6_HUMAN

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