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Human PDCD1 Recombinant Protein (RPPB4206)

SKU:
RPPB4206
Product Type:
Recombinant Protein
Species:
Human
Uniprot:
Q15116
$371
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Description

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Product Name:Human PDCD1 Recombinant Protein
Product Code:RPPB4206
Size:10µg
Species:Human
Target:PDCD1
Synonyms:Programmed Cell Death 1, Systemic Lupus Erythematosus Susceptibility 2, Protein PD-1, HPD-1, PD1, Programmed Cell Death 1 Protein, Programmed Cell Death Protein 1, CD279 Antigen, CD279, HPD-L, HSLE1, SLEB2, PD-1.
Source:Sf9 Insect cells
Physical Appearance:Sterile Filtered colorless solution.
Formulation:PDCD1 protein solution (0.5mg/ml) contains Phosphate Buffered Saline (pH 7.4) and 10% glycerol.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.�For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).�Avoid multiple freeze-thaw cycles.
Purity:Greater than 90.0% as determined by SDS-PAGE.
Amino Acid Sequence:ADPPGWFLDS PDRPWNPPTF SPALLVVTEG DNATFTCSFS NTSESFVLNW YRMSPSNQTD KLAAFPEDRS QPGQDCRFRV TQLPNGRDFH MSVVRARRND SGTYLCGAIS LAPKAQIKES LRAELRVTER RAEVPTAHPS PSPRPAGQFQ TLVLEPKSCD KTHTCPPCPA PELLGGPSVF LFPPKPKDTL MISRTPEVTC VVVDVSHEDP EVKFNWYVDG VEVHNAKTKP REEQYNSTYR VVSVLTVLHQ DWLNGKEYKC KVSNKALPAP IEKTISKAKG QPREPQVYTL PPSRDELTKN QVSLTCLVKG FYPSDIAVEW ESNGQPENNY KTTPPVLDSD GSFFLYSKLT VDKSRWQQGN VFSCSVMHEA LHNHYTQKSL SLSPGKHHHH HH

PDCD1 is a cell surface membrane protein of the immunoglobulin superfamily. PDCD1 is expressed in pro-B-cells and is thought to have a role in their differentiation. In mice, expression of PDCD1 gene is induced in the thymus when anti-CD3 antibodies are injected and large numbers of thymocytes undergo apoptosis. Mice deficient for the PDCD1 gene bred on a BALB/c background developed dilated cardiomyopathy and died from congestive heart failure. These studies suggest that the PDCD1 gene product may also be important in T cell function and contribute to the prevention of autoimmune diseases.

PDCD1 Human Recombinant produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain containing 392 amino acids (21-170a.a.) and having a molecular mass of 44.0kDa (Molecular size on SDS-PAGE will appear at approximately 40-57kDa).PDCD1 is expressed with a 239 amino acids hIgG-His tag at C-Terminus and purified by proprietary chromatographic techniques.

UniProt Protein Function:Inhibitory cell surface receptor involved in the regulation of T-cell function during immunity and tolerance. Upon ligand binding, inhibits T-cell effector functions in an antigen-specific manner. Possible cell death inducer, in association with other factors.
NCBI Summary:This gene encodes a cell surface membrane protein of the immunoglobulin superfamily. This protein is expressed in pro-B-cells and is thought to play a role in their differentiation. In mice, expression of this gene is induced in the thymus when anti-CD3 antibodies are injected and large numbers of thymocytes undergo apoptosis. Mice deficient for this gene bred on a BALB/c background developed dilated cardiomyopathy and died from congestive heart failure. These studies suggest that this gene product may also be important in T cell function and contribute to the prevention of autoimmune diseases. [provided by RefSeq, Jul 2008]
UniProt Code:Q15116
NCBI GenInfo Identifier:145559515
NCBI Gene ID:5133
NCBI Accession:Q15116.3
UniProt Secondary Accession:Q15116,Q02242,
UniProt Related Accession:Q15116
Molecular Weight:
NCBI Full Name:Programmed cell death protein 1
NCBI Synonym Full Names:programmed cell death 1
NCBI Official Symbol:PDCD1��
NCBI Official Synonym Symbols:PD1; PD-1; CD279; SLEB2; hPD-1; hPD-l; hSLE1��
NCBI Protein Information:programmed cell death protein 1
UniProt Protein Name:Programmed cell death protein 1
UniProt Synonym Protein Names:CD_antigen: CD279
UniProt Gene Name:PDCD1��

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