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Human PAX9 Recombinant Protein (RPPB4191)

SKU:
RPPB4191
Product Type:
Recombinant Protein
Species:
Human
Uniprot:
P55771
€309
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Description

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Product Name:Human PAX9 Recombinant Protein
Product Code:RPPB4191
Size:10µg
Species:Human
Target:PAX9
Synonyms:Paired Box 9, STHAG3, Paired Box Gene 9, Paired Box Protein Pax-9, Paired Domain Gene 9.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered clear solution.
Formulation:PAX9 protein solution (1mg/ml) containing 20mM Tris-HClbuffer (pH 8.0), 0.4M Urea and 10% glycerol.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 85.0% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MGSMEPAFGE VNQLGGVFVN GRPLPNAIRL RIVELAQLGI RPCDISRQLR VSHGCVSKIL ARYNETGSIL PGAIGGSKPR VTTPTVVKHI RTYKQRDPGI FAWEIRDRLL ADGVCDKYNV PSVSSISRIL RNKIGNLAQQ GHYDSYKQHQ PTPQPALPYN HIYSYPSPIT AAAAKVPTPP GVPAIPGSVA MPRTWPSSHS VTDILGIRSI TDQVSDSSPY HSPKVEEWSS LGRNNFPAAA PHAVNGLEKG ALEQEAKYGQ APNGLPAVGS FVSASSMAPY PTPAQVSPYM TYSAAPSGYV AGHGWQHAGG TSLSPHNCDI PASLAFKGMQ AAREGSHSVT ASAL

PAX9(Paired box protein Pax-9) belongs to the paired box (PAX) family of transcriptionfactors. Members of PAX9 family typically contain a paired box domain, anoctapeptide, and a paired-type homeodomain. These genes play critical rolesduring fetal development and cancer growth. In addition, PAX9 is vital for thedevelopment of different organs and skeletal elements.

PAX9 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 364 amino acids (1-341 a.a) and having a molecular mass of 38.7kDa.PAX9 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

UniProt Protein Function:PAX9: Transcription factor required for normal development of thymus, parathyroid glands, ultimobranchial bodies, teeth, skeletal elements of skull and larynx as well as distal limbs. Interacts with KDM5B.Protein type: Transcription factorChromosomal Location of Human Ortholog: 14q13.3Molecular Function: protein bindingBiological Process: negative regulation of transcription, DNA-dependentDisease: Tooth Agenesis, Selective, 3
UniProt Protein Details:
NCBI Summary:This gene is a member of the paired box (PAX) family of transcription factors. Members of this gene family typically contain a paired box domain, an octapeptide, and a paired-type homeodomain. These genes play critical roles during fetal development and cancer growth. Mice lacking this gene exhibit impaired development of organs, musculature and the skeleton, including absent and abnormally developed teeth, and neonatal lethality. Mutations in the human gene are associated with selective tooth agenesis-3. [provided by RefSeq, Sep 2015]
UniProt Code:P55771
NCBI GenInfo Identifier:8247954
NCBI Gene ID:5083
NCBI Accession:P55771.3
UniProt Secondary Accession:P55771,Q99582, Q9UQR4
UniProt Related Accession:P55771
Molecular Weight:36,310 Da
NCBI Full Name:Paired box protein Pax-9
NCBI Synonym Full Names:paired box 9
NCBI Official Symbol:PAX9��
NCBI Official Synonym Symbols:STHAG3��
NCBI Protein Information:paired box protein Pax-9
UniProt Protein Name:Paired box protein Pax-9
UniProt Synonym Protein Names:
Protein Family:Paired box protein
UniProt Gene Name:PAX9��
UniProt Entry Name:PAX9_HUMAN

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