Human OXSM Recombinant Protein (RPPB2062)
- SKU:
- RPPB2062
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- Q9NWU1
- Research Area:
- Enzymes
Description
| Product Name: | Human OXSM Recombinant Protein |
| Product Code: | RPPB2062 |
| Size: | 10µg |
| Species: | Human |
| Target: | OXSM |
| Synonyms: | 3-Oxoacyl-ACP Synthase Mitochondrial, Type II Mitochondrial Beta-Ketoacyl Synthase, 3-Ketoacyl-Acyl Carrier Protein Synthase, FASN2D, KASI, EC 2.3.1, Beta-Ketoacyl-ACP Synthase. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered clear solution. |
| Formulation: | The OXSM solution (0.5mg/ml) contains 20mM Tris-HCl buffer (pH8.0), 0.15M NaCl, 1mM DTT and 10% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 90.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MGSKRKFFGT VPISRLHRRV VITGIGLVTP LGVGTHLVWD RLIGGESGIV SLVGEEYKSI PCSVAAYVPR GSDEGQFNEQ NFVSKSDIKS MSSPTIMAIG AAELAMKDSG WHPQSEADQV ATGVAIGMGM IPLEVVSETA LNFQTKGYNK VSPFFVPKIL VNMAAGQVSI RYKLKGPNHA VSTACTTGAH AVGDSFRFIA HGDADVMVAG GTDSCISPLS LAGFSRARAL STNSDPKLAC RPFHPKRDGF VMGEGAAVLV LEEYEHAVQR RARIYAEVLG YGLSGDAGHI TAPDPEGEGA LRCMAAALKD AGVQPEEISY INAHATSTPL GDAAENKAIK HLFKDHAYAL AVSSTKGATG HLLGAAGAVE AAFTTLACYY QKLPPTLNLD CSEPEFDLNY VPLKAQEWKT EKRFIGLTNS FGFGGTNATL CIAGL |
OXSM, a beta-ketoacyl synthetase, is essential for elongation of fatty acid chains in the mitochondria. Alternatively spliced transcript variants were found.
OXSM Human Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 455 amino acids (28-459) and having a molecular mass of 48.1kDa.OXSM is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | OXSM: May play a role in the biosynthesis of lipoic acid as well as longer chain fatty acids required for optimal mitochondrial function. Belongs to the beta-ketoacyl-ACP synthases family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Transferase; EC 2.3.1.41; Lipid Metabolism - fatty acid biosynthesis; Mitochondrial Chromosomal Location of Human Ortholog: 3p24.2 Cellular Component: mitochondrion; cytoplasm Molecular Function:3-oxoacyl-[acyl-carrier-protein] synthase activity Biological Process: medium-chain fatty acid biosynthetic process; acyl-CoA metabolic process; short-chain fatty acid biosynthetic process |
| NCBI Summary: | This gene encodes a beta-ketoacyl synthetase. The encoded enzyme is required for elongation of fatty acid chains in the mitochondria. Alternatively spliced transcript variants have been described.[provided by RefSeq, Feb 2009] |
| UniProt Code: | Q9NWU1 |
| NCBI GenInfo Identifier: | 8923559 |
| NCBI Gene ID: | 54995 |
| NCBI Accession: | NP_060367.1 |
| UniProt Related Accession: | Q9NWU1 |
| Molecular Weight: | 49kDa |
| NCBI Full Name: | 3-oxoacyl-[acyl-carrier-protein] synthase, mitochondrial isoform 1 |
| NCBI Synonym Full Names: | 3-oxoacyl-ACP synthase, mitochondrial |
| NCBI Official Symbol: | OXSM�� |
| NCBI Official Synonym Symbols: | KS; CEM1; KASI; FASN2D�� |
| NCBI Protein Information: | 3-oxoacyl-[acyl-carrier-protein] synthase, mitochondrial |
| UniProt Protein Name: | 3-oxoacyl-[acyl-carrier-protein] synthase, mitochondrial |
| UniProt Synonym Protein Names: | Beta-ketoacyl-ACP synthase |
| Protein Family: | 3-oxoacyl-[acyl-carrier-protein] synthase |
| UniProt Gene Name: | OXSM�� |
| UniProt Entry Name: | OXSM_HUMAN |
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