Human OPRD-Strep full length protein-synthetic nanodisc (HDFP1106)
- SKU:
- HDFP1106
- Size:
- 10μg
- Target:
- OPRD
- Tag:
- C-Flag&Strep Tag
- Expression Host:
- HEK293
- Conjugate:
- Unconjugated
Description
| Product Name: | Nanodisc Human OPRD-Strep Protein |
| SKU: | HDFP1106 |
| Size: | 10μg |
| Target: | OPRD |
| Tag: | C-Flag&Strep Tag |
| Expression Host: | HEK293 |
| Conjugate: | Unconjugated |
| Synonyms: | DOP, DOR, DOR1, OPRD |
| Protein Families: | Transmembrane, Druggable Genome. |
| Protein Description: | Human OPRD-Strep full length protein-synthetic nanodisc |
| Protein Pathways: | GPCRDB Class A Rhodopsin-like, Peptide GPCRs, Autoimmune & Inflammatory Response, G-Protein Coupled Receptors Signaling Pathway, Na2 /NF-AT Signaling Pathways. |
| Molecular Weight: | The human full length OPRD-Strep protein has a MW of 40.4 kDa |
G-protein coupled receptor that functions as receptor for endogenous enkephalins and for a subset of other opioids. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling leads to the inhibition of adenylate cyclase activity. Inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance. Plays a role in the perception of pain and in opiate-mediated analgesia. Plays a role in developing analgesic tolerance to morphine.[UniProtKB/Swiss-Prot Function]
| Uniprot ID: | P41143 |
| Formulation & Reconstitution: | Lyophilized from nanodisc solubilization buffer (20 mM Tris-HCl, 150 mM NaCl, pH 8.0). Normally 5% – 8% trehalose is added as protectants before lyophilization. Please see Certificate of Analysis for specific instructions. Do not use solvents with a pH below 6.5 or those containing high concentrations of divalent metal ions (greater than 5 mM) in subsequent experiments. |
| Storage & Shipping: | Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature. |
| Usage: | Research use only |
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