Human ODC1 Recombinant Protein (RPPB2055)
- SKU:
- RPPB2055
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- P11926
- Research Area:
- Enzymes
Description
| Product Name: | Human ODC1 Recombinant Protein |
| Product Code: | RPPB2055 |
| Size: | 10µg |
| Species: | Human |
| Target: | ODC1 |
| Synonyms: | ODC, Ornithine decarboxylase 1, EC 4.1.1.17. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | The ODC1 solution (0.5mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 1mM DTT, 0.1M NaCl and 10% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 95% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MGSMNNFGNE EFDCHFLDEG FTAKDILDQK INEVSSSDDK DAFYVADLGD ILKKHLRWLK ALPRVTPFYA VKCNDSKAIV KTLAATGTGF DCASKTEIQL VQSLGVPPER IIYANPCKQV SQIKYAANNG VQMMTFDSEV ELMKVARAHP KAKLVLRIAT DDSKAVCRLS VKFGATLRTS RLLLERAKEL NIDVVGVSFH VGSGCTDPET FVQAISDARC VFDMGAEVGF SMYLLDIGGG FPGSEDVKLK FEEITGVINP ALDKYFPSDS GVRIIAEPGR YYVASAFTLA VNIIAKKIVL KEQTGSDDED ESSEQTFMYY VNDGVYGSFN CILYDHAHVK PLLQKRPKPD EKYYSSSIWG PTCDGLDRIV ERCDLPEMHV GDWMLFENMG AYTVAAASTF NGFQRPTIYY VMSGPAWQLM QQFQNPDFPP EVEEQDASTL PVSCAWESGM KRHRAACASA SINV |
Ornithine decarboxylase is the preliminary and rate-limiting enzyme in the biosynthetic pathway of polyamines and it takes part in the alteration of ornithine to putrescine. ODC1 is a key member of various biological processes, such as cell growth, transformation, differentiation and apoptosis. Overexpression of the ODC1 gene has a vital part in cell proliferation and the progress of cancer.
ODC1 Human Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 484 amino acids (1-461) and having a molecular mass of 53.5 kDa.ODC1 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | ODC: the rate-limiting enzyme of the polyamine biosynthesis pathway which catalyzes ornithine to putrescine. The activity level for the enzyme varies in response to growth-promoting stimuli and exhibits a high turnover rate in comparison to other mammalian proteins. Originally localized to both chromosomes 2 and 7, the gene encoding this enzyme has been determined to be located on 2p25, with a pseudogene located on 7q31-qter. [provided by RefSeq, Jul 2008] |
| UniProt Protein Details: | Protein type:Other Amino Acids Metabolism - glutathione; EC 4.1.1.17; Cell cycle regulation; Lyase; Amino Acid Metabolism - arginine and proline Chromosomal Location of Human Ortholog: 2p25 Cellular Component: cytoplasm; cytosol Molecular Function:ornithine decarboxylase activity; protein binding; protein homodimerization activity Biological Process: polyamine metabolic process; putrescine biosynthetic process from ornithine; regulation of amino acid metabolic process; regulation of protein catabolic process; response to virus Disease: Colorectal Cancer |
| NCBI Summary: | This gene encodes the rate-limiting enzyme of the polyamine biosynthesis pathway which catalyzes ornithine to putrescine. The activity level for the enzyme varies in response to growth-promoting stimuli and exhibits a high turnover rate in comparison to other mammalian proteins. Originally localized to both chromosomes 2 and 7, the gene encoding this enzyme has been determined to be located on 2p25, with a pseudogene located on 7q31-qter. Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Dec 2013] |
| UniProt Code: | P11926 |
| NCBI GenInfo Identifier: | 118377 |
| NCBI Gene ID: | 4953 |
| NCBI Accession: | P11926.2 |
| UniProt Secondary Accession: | P11926,Q53TU3, Q6LDS9, |
| UniProt Related Accession: | P11926 |
| Molecular Weight: | 51,148 Da |
| NCBI Full Name: | Ornithine decarboxylase |
| NCBI Synonym Full Names: | ornithine decarboxylase 1 |
| NCBI Official Symbol: | ODC1�� |
| NCBI Official Synonym Symbols: | ODC�� |
| NCBI Protein Information: | ornithine decarboxylase |
| UniProt Protein Name: | Ornithine decarboxylase |
| Protein Family: | Mitochondrial 2-oxodicarboxylate carrier |
| UniProt Gene Name: | ODC1�� |
| UniProt Entry Name: | DCOR_HUMAN |
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