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Human NUDT9 Recombinant Protein (RPPB2053)

SKU:
RPPB2053
Product Type:
Recombinant Protein
Species:
Human
Uniprot:
Q9BW91
Research Area:
Enzymes
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Description

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Product Name:Human NUDT9 Recombinant Protein
Product Code:RPPB2053
Size:20µg
Species:Human
Target:NUDT9
Synonyms:ADP-ribose pyrophosphatase mitochondrial, ADP-ribose diphosphatase, ADP-ribose phosphohydrolase, Adenosine diphosphoribose pyrophosphatase, ADPR-PPase, Nucleoside diphosphate-linked moiety X motif 9, Nudix motif 9, NUDT9, NUDT10, PSEC0099, UNQ3012/PRO9771.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered colorless solution.
Formulation:NUDT9 protein solution (1mg/ml) containing 20mM Tris-HCl buffer (pH 8.0), 10% glycerol, 1mM DTT and 0.1M NaCl.
Stability:NUDT9 Human Recombinant although stable at 4°C for 1 week, should be stored below -18°C. Please prevent freeze thaw cycles.
Purity:Greater than 95.0% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MNTNVMSGSN GSKENSHNKA RTSPYPGSKV ERSQVPNEKV GWLVEWQDYK PVEYTAVSVL AGPRWADPQI SESNFSPKFN EKDGHVERKS KNGLYEIENG RPRNPAGRTG LVGRGLLGRW GPNHAADPII TRWKRDSSGN KIMHPVSGKH ILQFVAIKRK DCGEWAIPGG MVDPGEKISA TLKREFGEEA LNSLQKTSAE KREIEEKLHK LFSQDHLVIY KGYVDDPRNT DNAWMETEAV NYHDETGEIM DNLMLEAGDD AGKVKWVDIN DKLKLYASHS QFIKLVAEKR DAHWSEDSEA DCHAL

NUDT9 is a member of a superfamily of Nudix hydrolases. NUDT9 functions as a highly specific adenosine diphosphate ribose pyrophosphatase which hydrolyzes ADP ribose to AMP and ribose 5'-phosphate. In addition, NUDT9 may be involved in the regulation of the menstrual cycle and may be related to the proliferation of glandular cells in the human endometrium.

NUDT9 produced in E.Coli is a single, non-glycosylated polypeptide chain containing 325 amino acids (47-350 a.a.) and having a molecular mass of 36.5kDa (molecular weight on SDS-PAGE will appear higher).NUDT9 is fused to a 21 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

UniProt Protein Function:NUDT9: Hydrolyzes ADP-ribose (ADPR) to AMP and ribose 5'- phosphate. Belongs to the Nudix hydrolase family. NudF subfamily. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:EC 3.6.1.13; Hydrolase; Mitochondrial; Nucleotide Metabolism - purine

Chromosomal Location of Human Ortholog: 4q22.1

Cellular Component: cell junction; mitochondrial matrix; mitochondrion; nuclear membrane

Molecular Function:adenosine-diphosphatase activity; ADP-ribose diphosphatase activity

NCBI Summary:The protein encoded by this gene belongs to the Nudix hydrolase family. Nudix boxes are found in a family of diverse enzymes that catalyze the hydrolysis of nucleoside diphosphate derivatives. This enzyme is an ADP-ribose pyrophosphatase that catalyzes the hydrolysis of ADP-ribose to AMP and ribose-5-P. It requires divalent metal ions and an intact Nudix motif for enzymatic activity. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
UniProt Code:Q9BW91
NCBI GenInfo Identifier:20455184
NCBI Gene ID:53343
NCBI Accession:Q9BW91.1
UniProt Secondary Accession:Q9BW91,Q8NBN1, Q8NCB9, Q8NG25,
UniProt Related Accession:Q9BW91
Molecular Weight:39kDa
NCBI Full Name:ADP-ribose pyrophosphatase, mitochondrial
NCBI Synonym Full Names:nudix hydrolase 9
NCBI Official Symbol:NUDT9��
NCBI Official Synonym Symbols:NUDT10��
NCBI Protein Information:ADP-ribose pyrophosphatase, mitochondrial
UniProt Protein Name:ADP-ribose pyrophosphatase, mitochondrial
UniProt Synonym Protein Names:ADP-ribose diphosphatase; ADP-ribose phosphohydrolase; Adenosine diphosphoribose pyrophosphatase; ADPR-PPase; Nucleoside diphosphate-linked moiety X motif 9; Nudix motif 9
Protein Family:Nudix hydrolase
UniProt Gene Name:NUDT9��

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