Human NTAL Recombinant Protein (RPPB4130)
- SKU:
- RPPB4130
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- Q9GZY6
Description
| Product Name: | Human NTAL Recombinant Protein |
| Product Code: | RPPB4130 |
| Size: | 25µg |
| Species: | Human |
| Target: | NTAL |
| Synonyms: | LAT2, Linker for Activation of T CellsFamily Member 2, HSPC046, LAB, WBSCR15, WBSCR5, WSCR5, Non-T-cell activation linker, Linker for activation of B-cells, Membrane-associated adapter molecule, Williams-Beuren syndrome chromosomal region 5 protein, Williams-Beuren syndrome chromosomal region 15 protein. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile filtered colorless solution. |
| Formulation: | NTAL Human solution containing 20mM Trsi HCL pH-8, & 10% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.�For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 80% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MRCSRPGAKR SEKIYQQRSL REDQQSFTGS RTYSLVGQAW PGPLADMAPT RKDKLLQFYP SLEDPASSRY QNFSKGSRHG SEEAYIDPIA MEYYNWGRFS KPPEDDDANS YENVLICKQK TTETGAQQEG IGGLCRGDLS LSLALKTGPT SGLCPSASPE EDEESEDYQN SASIHQWRES RKVMGQLQRE ASPGPVGSPD EEDGEPDYVN GEVAATEA |
NTAL participates in FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. NTAL takes part in BCR (B-cell antigen receptor)-mediated signaling in B-cells and FCGR1 (high affinity immunoglobulin gamma Fc receptor I)-mediated signaling in myeloid cells. Couples activation of these receptors and their associated kinases with distal intracellular events through the recruitment of GRB2.
NTAL Human Recombinant produced in E.Coli is a single, non-glycosylated,polypeptide chain containing 238 amino acids (27-243 a.a.) and having a molecular mass of 26.2 kDa. NTAL protein is fused to a 21 amino acid His tag at N-terminus and is purified by standard chromatography.
| UniProt Protein Function: | LAB: linker for activation of B cells (LAB) is an adaptor protein. B cell antigen receptor signaling leads to its phosphorylation and interaction with the adaptor protein Grb2. Decreased expression leads to a reduction in BCR-mediated calcium flux and Erk activation. Localized to lipid rafts. |
| UniProt Protein Details: | Protein type:Adaptor/scaffold; Membrane protein, integral Chromosomal Location of Human Ortholog: 7q11.23 Cellular Component: mast cell granule; integral to membrane; plasma membrane; lipid raft Molecular Function:protein binding; SH2 domain binding Biological Process: B cell receptor signaling pathway; B cell activation; calcium-mediated signaling; innate immune response; mast cell degranulation |
| NCBI Summary: | This gene is one of the contiguous genes at 7q11.23 commonly deleted in Williams syndrome, a multisystem developmental disorder. This gene consists of at least 14 exons, and its alternative splicing generates 3 transcript variants, all encoding the same protein. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q9GZY6 |
| NCBI GenInfo Identifier: | 74752543 |
| NCBI Gene ID: | 7462 |
| NCBI Accession: | Q9GZY6.1 |
| UniProt Secondary Accession: | Q9GZY6,Q9BXX8, Q9NZY9, A6NFK6, A8K209, A8K4F1, D3DXF9 |
| UniProt Related Accession: | Q9GZY6 |
| Molecular Weight: | 12,255 Da |
| NCBI Full Name: | Linker for activation of T-cells family member 2 |
| NCBI Synonym Full Names: | linker for activation of T cells family, member 2 |
| NCBI Official Symbol: | LAT2�� |
| NCBI Official Synonym Symbols: | LAB; NTAL; WSCR5; WBSCR5; HSPC046; WBSCR15�� |
| NCBI Protein Information: | linker for activation of T-cells family member 2; non-T-cell activation linker; linker for activation of B-cells; membrane-associated adapter molecule; Williams-Beuren syndrome chromosomal region 5 protein; Williams-Beuren syndrome chromosomal region 15 protein; linker for activation of T cells, transmembrane adaptor 2 |
| UniProt Protein Name: | Linker for activation of T-cells family member 2 |
| UniProt Synonym Protein Names: | Linker for activation of B-cells; Membrane-associated adapter molecule; Non-T-cell activation linker; Williams-Beuren syndrome chromosomal region 15 protein; Williams-Beuren syndrome chromosomal region 5 protein |
| Protein Family: | Linker for activation of T-cells family |
| UniProt Gene Name: | LAT2�� |
| UniProt Entry Name: | NTAL_HUMAN |
