Human NT 4 Recombinant Protein (RPPB0801)
- SKU:
- RPPB0801
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- P34130
- Research Area:
- Neurotrophins
Description
| Product Name: | Human NT 4 Recombinant Protein |
| Product Code: | RPPB0801 |
| Size: | 10µg |
| Species: | Human |
| Target: | NT 4 |
| Synonyms: | NT4, NT5, NTF5, NT-4/5, NTF4, Neurotrophin-4, Neutrophic factor 4, Neurotrophin-5, NT-5. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered White lyophilized (freeze-dried) powder. |
| Formulation: | Lyophilized from a concentrated (1mg/ml) solution in water containing 20mM phosphate buffer pH-7.4 and 150mM NaCl. |
| Solubility: | It is recommended to reconstitute the lyophilized NT-4 in sterile 18M?-cm H2O not less than 100�g/ml, which can then be further diluted to other aqueous solutions. |
| Stability: | Lyophilized NT-4 although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution NT-4 should be stored at 4°C between 2-7 days and for future use below -18°C.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please prevent freeze-thaw cycles. |
| Purity: | Greater than 97.0% as determined by:(a) Analysis by RP-HPLC.(b) Analysis by SDS-PAGE. |
| Amino Acid Sequence: | GVSETAPASR RGELAVCDAV SGWVTDRRTA VDLRGREVEV LGEVPAAGGS PLRQYFFETR CKADNAEEGG PGAGGGGCRG VDRRHWVSEC KAKQSYVRAL TADAQGRVGW RWIRIDTACV CTLLSRTGRA |
| Biological Activity: | Determined by the dose-dependent induction of choline acetyl transferase activity in rat basal forebrain primary septal cell cultures was found to be in the range of 20-50 ng/ml. |
NT-4 is part of the family of neurotrophic factors, neurotrophins, that are in charge for the survival and differentiation of mammalian neurons. NT-4 expression is dominant and less influenced by environmental signals. NT-4 deficient mice shows slight cellular deficits and develop normally to adulthood. NT-4 is a target-derived survival factor for peripheral sensory sympathetic neurons.NT-4 is involved in the proliferation and differentiation of periodontal ligament cells.
Neurotrophin-4 Human Recombinant produced in E.Coli is a noncovalently linked homodimer, non-glycosylated polypeptide chain containing 2 x 130 amino acids (81-210 amino acids) and having a total molecular mass of 28 kDa. The NT-4 is purified by proprietary chromatographic techniques.
| UniProt Protein Function: | NT-4/5: Target-derived survival factor for peripheral sensory sympathetic neurons. Defects in NTF4 may be associated with susceptibility to primary open angle glaucoma type 1O (GLC1O). A form of primary open angle glaucoma (POAG). POAG is characterized by a specific pattern of optic nerve and visual field defects. The angle of the anterior chamber of the eye is open, and usually the intraocular pressure is increased. The disease is asymptomatic until the late stages, by which time significant and irreversible optic nerve damage has already taken place. Belongs to the NGF-beta family. |
| UniProt Protein Details: | Protein type:Cytokine; Secreted; Cell development/differentiation; Secreted, signal peptide Chromosomal Location of Human Ortholog: 19q13.3 Cellular Component: endoplasmic reticulum lumen; cytoplasmic membrane-bound vesicle; extracellular region Molecular Function:neurotrophin p75 receptor binding; growth factor activity Biological Process: mechanoreceptor differentiation; epidermis development; cell-cell signaling; long-term memory; regulation of neuron differentiation; adult locomotory behavior; sensory organ boundary specification; ganglion mother cell fate determination; negative regulation of neuron apoptosis; transmembrane receptor protein tyrosine kinase signaling pathway; neurite morphogenesis Disease: Glaucoma 1, Open Angle, O |
| NCBI Summary: | This gene is a member of a family of neurotrophic factors, neurotrophins, that control survival and differentiation of mammalian neurons. The expression of this gene is ubiquitous and less influenced by environmental signals. While knock-outs of other neurotrophins including nerve growth factor, brain-derived neurotrophic factor, and neurotrophin 3 prove lethal during early postnatal development, NTF5-deficient mice only show minor cellular deficits and develop normally to adulthood. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P34130 |
| NCBI GenInfo Identifier: | 462741 |
| NCBI Gene ID: | 4909 |
| NCBI Accession: | P34130.1 |
| UniProt Secondary Accession: | P34130,Q6FH56, |
| UniProt Related Accession: | P34130,AAB20549 |
| Molecular Weight: | 210 |
| NCBI Full Name: | Neurotrophin-4 |
| NCBI Synonym Full Names: | neurotrophin 4 |
| NCBI Official Symbol: | NTF4�� |
| NCBI Official Synonym Symbols: | NT4; NT5; NT-4; NT-5; NTF5; GLC10; GLC1O; NT-4/5�� |
| NCBI Protein Information: | neurotrophin-4; neurotrophin-5; neutrophic factor 4; neurotrophic factor 4; neurotrophic factor 5; neurotrophin 5 (neurotrophin 4/5) |
| UniProt Protein Name: | Neurotrophin-4 |
| UniProt Synonym Protein Names: | Neurotrophin-5; NT-5; Neutrophic factor 4 |
| Protein Family: | Neurotrophin |
| UniProt Gene Name: | NTF4�� |
| UniProt Entry Name: | NTF4_HUMAN |
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