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Human NODAL / Nodal homolog ELISA Kit

SKU:
HUFI01135
Product Type:
ELISA Kit
Size:
96 Assays
Uniprot:
Q96S42
Sensitivity:
46.875pg/ml
Range:
78.125-5000pg/ml
ELISA Type:
Sandwich
Synonyms:
NODAL, Nodal homolog
Reactivity:
Human
Research Area:
Cell Biology
€599
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Description

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Human NODAL / Nodal homolog ELISA Kit

The TGF-beta (transforming growth factor-beta) superfamily of proteins encodes a secreted ligand. Ligands in this family bind to TGF-beta receptors, causing SMAD family transcription factors to be recruited and activated, which regulate gene expression. The mature protein, which regulates early embryonic development, is produced by proteolytic processing of the encoded preproprotein. NODAL/Nodal homolog is required for the pluripotency of human embryonic stem cells and may be involved in placental development. Heterotaxy is a condition characterised by the random orientation of visceral organs in relation to the left-right axis, which is linked to mutations in this gene. Heterotaxy, Visceral, 5, Autosomal, and Visceral Heterotaxy are diseases linked to NODAL. Signaling by NODAL and Tgif disruption of Shh signalling are two related pathways to NODAL/Nodal homolog.