Human NHLH1 Recombinant Protein (RPPB4093)
- SKU:
- RPPB4093
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- Q02575
Description
| Product Name: | Human NHLH1 Recombinant Protein |
| Product Code: | RPPB4093 |
| Size: | 5µg |
| Species: | Human |
| Target: | NHLH1 |
| Synonyms: | Nescient Helix Loop Helix 1, Class A Basic Helix-Loop-Helix Protein 35, Helix-Loop-Helix Protein 1, BHLHA35, NSCL1, HEN1. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered clear solution. |
| Formulation: | The NHLH1 solution (0.25mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 0.2M NaCl, 2mM DTT and 40% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 85% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MGSMMLNSDT MELDLPPTHS ETESGFSDCG GGAGPDGAGP GGPGGGQARG PEPGEPGRKD LQHLSREERR RRRRATAKYR TAHATRERIR VEAFNLAFAE LRKLLPTLPP DKKLSKIEIL RLAICYISYL NHVLDV |
HLH (helix-loop-helix) proteins are a putative transcription factors family. Several HLH proteins take part in growth and development of an extensive range of tissues and species. NHLH1 functions as a DNA-binding protein and has a role in the regulation of cell-type determination in the developing nervous system.
NHLH1 Human Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 156 amino acids (1-133) and having a molecular mass of 17.0kDa.NHLH1 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | NHLH1: May serve as DNA-binding protein and may be involved in the control of cell-type determination, possibly within the developing nervous system. |
| UniProt Protein Details: | Chromosomal Location of Human Ortholog: 1q22 Cellular Component: nucleus Biological Process: central nervous system development; positive regulation of transcription from RNA polymerase II promoter |
| NCBI Summary: | The helix-loop-helix (HLH) proteins are a family of putative transcription factors, some of which have been shown to play an important role in growth and development of a wide variety of tissues and species. Four members of this family have been clearly implicated in tumorigenesis via their involvement in chromosomal translocations in lymphoid tumors: MYC (MIM 190080), LYL1 (MIM 151440), E2A (MIM 147141), and SCL (MIM 187040).[supplied by OMIM, Nov 2002] |
| UniProt Code: | Q02575 |
| NCBI GenInfo Identifier: | 399885 |
| NCBI Gene ID: | 4807 |
| NCBI Accession: | Q02575.1 |
| UniProt Related Accession: | Q02575 |
| Molecular Weight: | 14,618 Da |
| NCBI Full Name: | Helix-loop-helix protein 1 |
| NCBI Synonym Full Names: | nescient helix-loop-helix 1 |
| NCBI Official Symbol: | NHLH1�� |
| NCBI Official Synonym Symbols: | HEN1; NSCL; NSCL1; bHLHa35�� |
| NCBI Protein Information: | helix-loop-helix protein 1 |
| UniProt Protein Name: | Helix-loop-helix protein 1 |
| UniProt Synonym Protein Names: | Class A basic helix-loop-helix protein 35; bHLHa35; Nescient helix loop helix 1; NSCL-1 |
| Protein Family: | Helix-loop-helix protein |
| UniProt Gene Name: | NHLH1�� |
| UniProt Entry Name: | HEN1_HUMAN |
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