Human NGFR Recombinant Protein (RPPB0788)
- SKU:
- RPPB0788
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- P08138
- Research Area:
- Neurotrophins
Description
| Product Name: | Human NGFR Recombinant Protein |
| Product Code: | RPPB0788 |
| Size: | 10µg |
| Species: | Human |
| Target: | NGFR |
| Synonyms: | Tumor necrosis factor receptor superfamily member 16, Gp80-LNGFR, Low affinity neurotrophin receptor p75NTR, Low-affinity nerve growth factor receptor, NGF receptor, p75 ICD, CD271. |
| Source: | Sf9 Insect cells |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | NGFR protein solution (1mg/ml) contains PhosphateBuffered Saline (pH 7.4) and 10% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.�For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).�Avoid multiple freeze-thaw cycles. |
| Purity: | Greaterthan 95.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | KEACPTGLYT HSGECCKACN LGEGVAQPCG ANQTVCEPCL DSVTFSDVVS ATEPCKPCTE CVGLQSMSAP CVEADDAVCR CAYGYYQDET TGRCEACRVC EAGSGLVFSC QDKQNTVCEE CPDGTYSDEA NHVDPCLPCT VCEDTERQLR ECTRWADAEC EEIPGRWITR STPPEGSDST APSTQEPEAP PEQDLIASTV AGVVTTVMGS SQPVVTRGTT DNLEHHHHHH |
Tumor necrosis factor receptor superfamily member 16 (NGFR) BELONGS TO the tumor necrosis factor receptor superfamily with an extensive pattern of expression in tissues such as the brain, liver, lung, and muscle. NGFR has a role in the regulation of the translocation of GLUT4 to the cell surface in adipocytes and skeletal muscle cells in response to insulin, possibly by regulating RAB31 activity, and thus contributes to the regulation of insulin-dependent glucose uptake. NGFRs are low affinity receptors which can bind to NGF, BDNF, NT-3, and NT-4. NGFR mediates cell survival as well as cell death of neural cells.
NGFR produced in Sf9 Baculovirus cells is a single,glycosylated polypeptide chain containing 230 amino acids (29-250 a.a.) andhaving a molecular mass of 24.6kDa (Migrates at 40-57kDa on SDS-PAGE underreducing conditions).NGFR is expressed with an 8 amino acid His tag at C-Terminus and purified byproprietary chromatographic techniques.
| UniProt Protein Function: | NGFR: Low affinity receptor which can bind to NGF, BDNF, NT-3, and NT-4. Can mediate cell survival as well as cell death of neural cells. Homodimer; disulfide-linked. Interacts with p75NTR- associated cell death executor. Interacts with TRAF2, TRAF4, TRAF6, PTPN13 and RANBP9. Interacts through TRAF6 with SQSTM1 which bridges NGFR to NTRK1. Interacts with BEX1 and NGFRAP1/BEX3. Interacts with KIDINS220 and NTRK1. Can form a ternary complex with NTRK1 and KIDINS220 and this complex is affected by the expression levels of KIDINS220. An increase in KIDINS220 expression leads to a decreased association of NGFR and NTRK1. Interacts with NTRK2; may regulate the ligand specificity of the NTRK2 receptor. Interacts with LINGO1. |
| UniProt Protein Details: | Protein type:Receptor, misc.; Membrane protein, integral Chromosomal Location of Human Ortholog: 17q21-q22 Cellular Component: cell surface; clathrin-coated endocytic vesicle; cytosol; endosome; external side of plasma membrane; extracellular region; Golgi apparatus; integral to plasma membrane; lipid raft; neuron projection; nuclear envelope; nucleoplasm; nucleus; perikaryon; plasma membrane; rough endoplasmic reticulum Molecular Function:beta-amyloid binding; nerve growth factor binding; neurotrophin TRKA receptor binding; protein binding; Rab GTPase binding; receptor activity; signal transducer activity; transmembrane receptor activity; tumor necrosis factor receptor activity; ubiquitin protein ligase binding Biological Process: axon guidance; central nervous system development; circadian regulation of gene expression; detection of temperature stimulus; glucose homeostasis; hair follicle morphogenesis; immune response; inflammatory response; intracellular protein transport; membrane protein intracellular domain proteolysis; negative regulation of apoptosis; negative regulation of axonogenesis; negative regulation of cell cycle; negative regulation of fibroblast growth factor receptor signaling pathway; negative regulation of hair follicle development; negative regulation of mitochondrial depolarization; negative regulation of neuron apoptosis; nerve development; nerve growth factor receptor signaling pathway; positive regulation of apoptosis; positive regulation of axonogenesis; positive regulation of fibroblast proliferation; positive regulation of MAPKKK cascade; positive regulation of myelination; positive regulation of odontogenesis of dentine-containing teeth; positive regulation of protein kinase B signaling cascade; positive regulation of Rho protein signal transduction; positive regulation of synaptic transmission, cholinergic; positive regulation of synaptic transmission, glutamatergic; regulation of apoptosis; regulation of axonogenesis; regulation of caspase activity; regulation of cell proliferation; response to lipopolysaccharide; response to wounding; sensory perception of pain; tumor necrosis factor-mediated signaling pathway |
| NCBI Summary: | Nerve growth factor receptor contains an extracellular domain containing four 40-amino acid repeats with 6 cysteine residues at conserved positions followed by a serine/threonine-rich region, a single transmembrane domain, and a 155-amino acid cytoplasmic domain. The cysteine-rich region contains the nerve growth factor binding domain. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P08138 |
| NCBI GenInfo Identifier: | 128156 |
| NCBI Gene ID: | 4804 |
| NCBI Accession: | P08138.1 |
| UniProt Secondary Accession: | P08138,B2R961, B4E096, |
| UniProt Related Accession: | P08138 |
| Molecular Weight: | 35,767 Da |
| NCBI Full Name: | Tumor necrosis factor receptor superfamily member 16 |
| NCBI Synonym Full Names: | nerve growth factor receptor |
| NCBI Official Symbol: | NGFR�� |
| NCBI Official Synonym Symbols: | CD271; p75NTR; TNFRSF16; p75(NTR); Gp80-LNGFR�� |
| NCBI Protein Information: | tumor necrosis factor receptor superfamily member 16 |
| UniProt Protein Name: | Tumor necrosis factor receptor superfamily member 16 |
| UniProt Synonym Protein Names: | Gp80-LNGFR; Low affinity neurotrophin receptor p75NTR; Low-affinity nerve growth factor receptor; NGF receptor; p75 ICD; CD_antigen: CD271 |
| Protein Family: | Tumor necrosis factor receptor superfamily |
| UniProt Gene Name: | NGFR�� |
| UniProt Entry Name: | TNR16_HUMAN |
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