The Human Neurogranin Polyclonal Antibody is a vital tool for researchers studying neurogranin, a protein found in the brain that is essential for regulating synaptic plasticity and memory formation. This polyclonal antibody, produced in rabbits, has been extensively validated for use in various applications, including Western blotting and immunohistochemistry.Neurogranin is a key player in neuronal signaling and plasticity, making it a key target for research in neuroscience and neurodegenerative diseases.
By targeting neurogranin with this antibody, researchers can accurately detect and analyze its expression in human samples, providing valuable insights into its role in neurological function and dysfunction.With its high specificity and sensitivity, the Human Neurogranin Polyclonal Antibody is a valuable tool for advancing our understanding of neurogranin's function in the brain, potentially leading to new insights and therapeutic strategies for neurological disorders.
Product Name:
Human Neurogranin Polyclonal Antibody
SKU:
CAB22030
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 2-78 of human Human Neurogranin (NP_001119653.1).
Neurogranin (NRGN) is the human homolog of the neuron-specific rat RC3/neurogranin gene. This gene encodes a postsynaptic protein kinase substrate that binds calmodulin in the absence of calcium. The NRGN gene contains four exons and three introns. The exons 1 and 2 encode the protein and exons 3 and 4 contain untranslated sequences. It is suggested that the NRGN is a direct target for thyroid hormone in human brain, and that control of expression of this gene could underlay many of the consequences of hypothyroidism on mental states during development as well as in adult subjects.
Purification Method:
Affinity purification
Gene ID:
4900
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using Human Neurogranin antibody (CAB22030) at 1:400 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 60s.
