Human NEUROG3 Recombinant Protein (RPPB0783)
- SKU:
- RPPB0783
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- Q9Y4Z2
- Research Area:
- Neurotrophins
Description
| Product Name: | Human NEUROG3 Recombinant Protein |
| Product Code: | RPPB0783 |
| Size: | 10µg |
| Species: | Human |
| Target: | NEUROG3 |
| Synonyms: | Neurogenin 3, Class A Basic Helix-Loop-Helix Protein 7, Protein Atonal Homolog 5, BHLHA7, Math4B, NGN3, Atoh5. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered clear solution. |
| Formulation: | The NEUROG3 solution (0.25mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 0.4M Urea and 10% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 85% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MTPQPSGAPT VQVTRETERS FPRASEDEVT CPTSAPPSPT RTRGNCAEAE EGGCRGAPRK LRARRGGRSR PKSELALSKQ RRSRRKKAND RERNRMHNLN SALDALRGVL PTFPDDAKLT KIETLRFAHN YIWALTQTLR IADHSLYALE PPAPHCGELG SPGGSPGDWG SLYSPVSQAG SLSPAASLEE RPGLLGATSS ACLSPGSLAF SDFL |
NEUROG3 is a common helix-loop-helix (bHLH) transcription factor which takes part in neurogenesis. NEUROG3 functions as a heterodimer with another bHLH protein. Mutations in this gene can result in congenital malabsorptive diarrhea 4 (DIAR4).
NEUROG3 Human Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 234 amino acids (1-214) and having a molecular mass of 25.1 kDa. NEUROG3 is fused to a 20 amino acid His-tag at N-terminus.
| UniProt Protein Function: | neurogenin 3: Acts as a transcriptional regulator. Together with NKX2- 2, initiates transcriptional activation of NEUROD1. Involved in neurogenesis. Also required for the specification of a common precursor of the 4 pancreatic endocrine cell types. Defects in NEUROG3 are the cause of diarrhea type 4 (DIAR4). DIAR4 is a characterized by severe, life- threatening watery diarrhea associated with generalized malabsorption and a paucity of enteroendocrine cells. |
| UniProt Protein Details: | Protein type:Cell development/differentiation; Transcription factor; DNA-binding Chromosomal Location of Human Ortholog: 10q21.3 Cellular Component: cytoplasm; nucleus Molecular Function:protein dimerization activity; chromatin DNA binding; double-stranded DNA binding; transcription coactivator activity Biological Process: nervous system development; central nervous system development; transcription, DNA-dependent; regulation of dendrite morphogenesis; negative regulation of transcription from RNA polymerase II promoter; endocrine pancreas development; peripheral nervous system development; epithelial cell differentiation; spinal cord development; forebrain development; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription factor activity; positive regulation of neuron differentiation; hindbrain development Disease: Diarrhea 4, Malabsorptive, Congenital |
| NCBI Summary: | The protein encoded by this gene is a basic helix-loop-helix (bHLH) transcription factor involved in neurogenesis. The encoded protein likely acts as a heterodimer with another bHLH protein. Defects in this gene are a cause of congenital malabsorptive diarrhea 4 (DIAR4).[provided by RefSeq, May 2010] |
| UniProt Code: | Q9Y4Z2 |
| NCBI GenInfo Identifier: | 229462908 |
| NCBI Gene ID: | 50674 |
| NCBI Accession: | Q9Y4Z2.2 |
| UniProt Secondary Accession: | Q9Y4Z2,Q5VVI0, Q6DJX6, Q9BY24, |
| UniProt Related Accession: | Q9Y4Z2 |
| Molecular Weight: | 214 |
| NCBI Full Name: | Neurogenin-3 |
| NCBI Synonym Full Names: | neurogenin 3 |
| NCBI Official Symbol: | NEUROG3�� |
| NCBI Official Synonym Symbols: | ngn3; Atoh5; NGN-3; Math4B; bHLHa7�� |
| NCBI Protein Information: | neurogenin-3; protein atonal homolog 5; class A basic helix-loop-helix protein 7 |
| UniProt Protein Name: | Neurogenin-3 |
| UniProt Synonym Protein Names: | Class A basic helix-loop-helix protein 7; bHLHa7; Protein atonal homolog 5 |
| UniProt Gene Name: | NEUROG3�� |
| UniProt Entry Name: | NGN3_HUMAN |
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