Human NCL Recombinant Protein (RPPB4067)
- SKU:
- RPPB4067
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- P19338
Description
| Product Name: | Human NCL Recombinant Protein |
| Product Code: | RPPB4067 |
| Size: | 10µg |
| Species: | Human |
| Target: | NCL |
| Synonyms: | Nucleolin, Protein C23, NCL, C23. |
| Source: | Sf9 Insect cells |
| Physical Appearance: | Sterile Filtered clear solution. |
| Formulation: | NCL is supplied in 20mM HEPES pH-7.3, 600mM NaCl, 0.3mM Tris(2-carboxyethyl)phosphine (TCEP) and 25% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 80.0% as determined by SDS-PAGE. |
Nucleolin (NCL) which is a eukaryotic nucleolar phosphoprotein, involved in the synthesis and maturation of ribosomes. Nucleolin is the key nucleolar protein of growing eukaryotic cells. NCL is found linked with intranucleolar chromatin and pre-ribosomal particles. NCL induces chromatin decondensation by binding to histone H1. Nucleolin is assumed to have a role in pre-rRNA transcription and ribosome compilation. Nucleolin may also have a role in the process of transcriptional elongation. Nucleolin is located primarily in the dense fibrillar regions of the nucleolus. The Human NCL gene consists of 14 exons with 13 introns and spans approximately 11kb.
Nucleolin Human Recombinant produced in SF9 is a glycosylated, polypeptide chain containing the C-terminal section of the human nucleolin and missing the N-terminal histone-binding part of nucleolin, having a calculated molecular mass of 55,162 Dalton. NCL is expressed with a -6x His tag at N-terminus and purified by proprietary chromatographic techniques.
| UniProt Protein Function: | NCL: the major nucleolar protein of growing eukaryotic cells. It is found associated with intranucleolar chromatin and preribosomal particles. It induces chromatin decondensation by binding to histone H1. It is thought to play a role in pre-RNA transcription and ribosome assembly. |
| UniProt Protein Details: | Protein type:Helicase; RNA-binding; Nucleolus; Nuclear receptor co-regulator; DNA-binding Chromosomal Location of Human Ortholog: 2q37.1 Cellular Component: cell cortex; membrane; nucleolus; nucleoplasm; nucleus; ribonucleoprotein complex Molecular Function:identical protein binding; protein binding; protein C-terminus binding; RNA binding; telomeric DNA binding Biological Process: angiogenesis |
| NCBI Summary: | Nucleolin (NCL), a eukaryotic nucleolar phosphoprotein, is involved in the synthesis and maturation of ribosomes. It is located mainly in dense fibrillar regions of the nucleolus. Human NCL gene consists of 14 exons with 13 introns and spans approximately 11kb. The intron 11 of the NCL gene encodes a small nucleolar RNA, termed U20. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P19338 |
| NCBI GenInfo Identifier: | 90110781 |
| NCBI Gene ID: | 4691 |
| NCBI Accession: | P19338.3 |
| UniProt Secondary Accession: | P19338,Q53SK1, Q8NB06, Q9UCF0, Q9UDG1, |
| UniProt Related Accession: | P19338 |
| Molecular Weight: | 76,614 Da |
| NCBI Full Name: | Nucleolin |
| NCBI Synonym Full Names: | nucleolin |
| NCBI Official Symbol: | NCL�� |
| NCBI Official Synonym Symbols: | C23�� |
| NCBI Protein Information: | nucleolin |
| UniProt Protein Name: | Nucleolin |
| UniProt Synonym Protein Names: | Protein C23 |
| Protein Family: | Nucleolin |
| UniProt Gene Name: | NCL�� |
| UniProt Entry Name: | NUCL_HUMAN |
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