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Human NAPG Recombinant Protein (RPPB4237)

SKU:
RPPB4237
Product Type:
Recombinant Protein
Species:
Human
Uniprot:
Q99747
$371
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Description

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Product Name:Human NAPG Recombinant Protein
Product Code:RPPB4237
Size:20µg
Species:Human
Target:NAPG
Synonyms:Gamma-soluble NSF attachment protein, SNAP-gamma, N-ethylmaleimide-sensitive factor attachment protein gamma, NAPG, SNAPG, GAMMASNAP.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered colorless solution.
Formulation:NAPG protein solution (1mg/ml) containing 20mM Tris-HCl buffer (pH8.0), 10% glycerol, 0.1M NaCl and 1mM DTT.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 95.0% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MGSHMAAQKI NEGLEHLAKA EKYLKTGFLK WKPDYDSAAS EYGKAAVAFK NAKQFEQAKD ACLREAVAHE NNRALFHAAK AYEQAGMMLK EMQKLPEAVQ LIEKASMMYL ENGTPDTAAM ALERAGKLIE NVDPEKAVQL YQQTANVFEN EERLRQAVEL LGKASRLLVR GRRFDEAALS IQKEKNIYKE IENYPTCYKK TIAQVLVHLH RNDYVAAERC VRESYSIPGF NGSEDCAALE QLLEGYDQQD QDQVSDVCNS PLFKYMDNDY AKLGLSLVVP GGGIKKKSPA TPQAKPDGVT ATAADEEEDE YSGGLC

Gamma-SNAP (NAPG) is a cytoplasmic protein which binds to a membrane receptor complex composed of VAMP, SNAP25 and syntaxin. NAPG mediates the membrane binding of NSF, which is crucial for membrane fusion reactions. NSF and SNAPs seem to be general components of the intracellular membrane fusion system, and their action at specific sites of fusion needs be controlled by SNAP receptors specific to the membranes being fused. NAPG mediates platelet exocytosis and controls the membrane fusion events of this process.

NAPG Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 336 amino acids (1-312 a.a.) and having a molecular mass of 37.3kDa.NAPG is fused to a 24 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

UniProt Protein Function:SNAP-gamma: a cytoplasmic peripheral membrane protein that mediates platelet exocytosis and controls the membrane fusion events of this process. Required for vesicular transport between the endoplasmic reticulum and the Golgi apparatus.
UniProt Protein Details:

Protein type:Vesicle

Chromosomal Location of Human Ortholog: 18p11.22

Cellular Component: lysosomal membrane; mitochondrion; SNARE complex

Molecular Function:protein binding; soluble NSF attachment protein activity; syntaxin binding

Biological Process: intra-Golgi vesicle-mediated transport; intracellular protein transport

NCBI Summary:This gene encodes soluble NSF attachment protein gamma. The soluble NSF attachment proteins (SNAPs) enable N-ethyl-maleimide-sensitive fusion protein (NSF) to bind to target membranes. NSF and SNAPs appear to be general components of the intracellular membrane fusion apparatus, and their action at specific sites of fusion must be controlled by SNAP receptors particular to the membranes being fused. The product of this gene mediates platelet exocytosis and controls the membrane fusion events of this process.[provided by RefSeq, Dec 2008]
UniProt Code:Q99747
NCBI GenInfo Identifier:3024632
NCBI Gene ID:8774
NCBI Accession:Q99747.1
UniProt Secondary Accession:Q99747,Q9BUV1, B4DFC9,
UniProt Related Accession:Q99747
Molecular Weight:25,662 Da
NCBI Full Name:Gamma-soluble NSF attachment protein
NCBI Synonym Full Names:NSF attachment protein gamma
NCBI Official Symbol:NAPG��
NCBI Official Synonym Symbols:GAMMASNAP��
NCBI Protein Information:gamma-soluble NSF attachment protein
UniProt Protein Name:Gamma-soluble NSF attachment protein
UniProt Synonym Protein Names:N-ethylmaleimide-sensitive factor attachment protein gamma
Protein Family:Ferredoxin-type protein
UniProt Gene Name:NAPG��
UniProt Entry Name:SNAG_HUMAN

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