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Human NANOGP8 Recombinant Protein (RPPB4055)

SKU:
RPPB4055
Product Type:
Recombinant Protein
Species:
Human
Uniprot:
Q6NSW7
€309
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Description

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Product Name:Human NANOGP8 Recombinant Protein
Product Code:RPPB4055
Size:10µg
Species:Human
Target:NANOGP8
Synonyms:Nanog Homeobox Pseudogene 8, NANOG, NANOGP1, PN8.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered clear solution.
Formulation:The NANOGP8 solution (1mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 0.4M Urea and 5% glycerol.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 85% as determined by SDS-PAGE.
Amino Acid Sequence:MSVDPACPQS LPCFEASDCK ESSPMPVICG PEENYPSLQM SSAEMPHTET VSPLPSSMDL LIQDSPDSST SPKGKQPTSA ENSVAKKEDK VPVKKQKTRT VFSSTQLCVL NDRFQRQKYL SLQQMQELSN ILNLSYKQVK TWFQNQRMKS KRWQKNNWPK NSNGVTQKAS APTYPSLYSS YHQGCLVNPT GNLPMWSNQT WNNSTWSNQT QNIQSWSNHS WNTQTWCTQS WNNQAWNSPF YNCGEESLQS CMHFQPNSPA SDLEAALEAA GEGLNVIQQT TRYFSTPQTM DLFLNYSMNM QPEDV

NANOGP8 belongs to the homeobox family of DNA binding transcription factors which is known to conserve pluripotency of embryonic stem cells. One change only separate NANOGP8 from NANOG � instead of 'Gln-253' in the inferred amino acid sequence in NANOG there is a �His-253� in NANOGP8.

NANOGP8 Human Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 305 amino acids (1-305) and having a molecular mass of 34.6kDa.NANOGP8 is purified by proprietary chromatographic techniques.

UniProt Protein Function:May act as a transcription regulator (). When overexpressed, promotes entry of cells into S phase and cell proliferation.
UniProt Protein Details:
NCBI Summary:This locus is a processed pseudogene of the transcription factor NANOG. NANOG plays a central role in regulating self-renewal in pluripotent stem cells and tumor cells. This pseudogene contains an intact open reading frame that could potentially encode a protein similar to NANOG. Although there is no evidence of transcription from this pseudogene, RT-PCR studies suggest that NANOGP8 may be expressed in some cancer cell lines. In vitro studies using a recombinant NANOGP8 protein have shown that the protein localizes to the nucleus and can promote cell proliferation, similar to NANOG. [provided by RefSeq, Sep 2009]
UniProt Code:Q6NSW7
NCBI GenInfo Identifier:74762336
NCBI Gene ID:388112
NCBI Accession:Q6NSW7.1
UniProt Secondary Accession:Q6NSW7
UniProt Related Accession:Q6NSW7
Molecular Weight:34,615 Da
NCBI Full Name:Putative homeobox protein NANOGP8
NCBI Synonym Full Names:Nanog homeobox pseudogene 8
NCBI Official Symbol:NANOGP8��
NCBI Official Synonym Symbols:PN8; NANOG; NANOGP1��
NCBI Protein Information:
UniProt Protein Name:Putative homeobox protein NANOGP8
UniProt Synonym Protein Names:
Protein Family:
UniProt Gene Name:NANOGP8��
UniProt Entry Name:NANP8_HUMAN

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