Human Myostatin Recombinant Protein (RPPB0779)
- SKU:
- RPPB0779
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- O14793
- Research Area:
- Growth Factors & Cytokines
Description
| Product Name: | Human Myostatin Recombinant Protein |
| Product Code: | RPPB0779 |
| Size: | 10µg |
| Species: | Human |
| Target: | Myostatin |
| Synonyms: | GDF-8, MSTN, Growth Differentiation Factor 8, MSTN Muscle Hypertrophy. |
| Source: | HEK293 Cells |
| Physical Appearance: | Filtered colorless solution. |
| Formulation: | Myostatin solution at a concentration of 0.25mg/ml in phosphate buffered saline (PBS) pH 8.0 and 20% (w/v) glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 95.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | HHHHHHASNE NSEQKENVEK EGLCNACTWR QNTKSSRIEA IKIQILSKLR LETAPNISKD VIRQLLPKAP PLRELIDQYD VQRDDSSDGS LEDDDYHATT ETIITMPTES DFLMQVDGKP KCCFFKFSSK IQYNKVVKAQ LWIYLRPVET PTTVFVQILR LIKPMKDGTR YTGIRSLKLD MNPGTGIWQS IDVKTVLQNW LKQPESNLGI EIKALDENGH DLAVTFPGPG EDGLNPFLEV KVTDTPKRSR RDFGLDCDEH STESRCCRYP LTVDFEAFGW DWIIAPKRYK ANYCSGECEF VFLQKYPHTH LVHQANPRGS AGPCCTPTKM SPINMLYFNG KEQIIYGKIP AMVVDRCGCS |
GDF8 is a member of the bone morphogenetic protein (BMP) family and the TGF-beta superfamily. This group of proteins is characterized by a polybasic proteolytic processing site which is cleaved to produce a mature protein containing seven conserved cysteine residues. The members of this family are regulators of cell growth and differentiation in both embryonic and adult tissues. This gene is thought to encode a secreted protein which negatively regulates skeletal muscle growth.
Myostatin Human Recombinant produced in HEK cells is a single, glycosylated, polypeptide chain (Asn24-Ser375) containing a total of 360 amino acids, having a calculated molecular mass of 41.1kDa. Myostatin is fused to a 2 aa N-terminal linker and a 6 aa His tag at N-Terminus.
| UniProt Protein Function: | MSTN: Acts specifically as a negative regulator of skeletal muscle growth. Defects in MSTN are the cause of muscle hypertrophy (MSLHP). MSLHP is a condition characterized by increased muscle bulk and strength. Affected individuals are exceptionally strong. Belongs to the TGF-beta family. |
| UniProt Protein Details: | Protein type:Secreted; Secreted, signal peptide Chromosomal Location of Human Ortholog: 2q32.2 Cellular Component: extracellular space Molecular Function:cytokine activity; identical protein binding; protein binding; receptor binding; transforming growth factor beta receptor binding Biological Process: cell development; muscle development; muscle maintenance; negative regulation of myoblast differentiation; negative regulation of protein kinase B signaling cascade; negative regulation of skeletal muscle growth; positive regulation of transcription, DNA-dependent; regulation of apoptosis; regulation of MAPKKK cascade Disease: Muscle Hypertrophy |
| UniProt Code: | O14793 |
| NCBI GenInfo Identifier: | 4885259 |
| NCBI Gene ID: | 2660 |
| NCBI Accession: | NP_005250.1 |
| UniProt Secondary Accession: | O14793,Q6B0H2, A1C2J7, A1C2K0, |
| UniProt Related Accession: | O14793 |
| Molecular Weight: | 42,750 Da |
| NCBI Full Name: | growth/differentiation factor 8 preproprotein |
| NCBI Synonym Full Names: | myostatin |
| NCBI Official Symbol: | MSTN�� |
| NCBI Official Synonym Symbols: | GDF8; MSLHP�� |
| NCBI Protein Information: | growth/differentiation factor 8 |
| UniProt Protein Name: | Growth/differentiation factor 8 |
| UniProt Synonym Protein Names: | Myostatin |
| Protein Family: | Growth/differentiation factor |
| UniProt Gene Name: | MSTN�� |
| UniProt Entry Name: | GDF8_HUMAN |
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