Human Myostatin Recombinant Protein (RPPB0778)
- SKU:
- RPPB0778
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- O14793
- Research Area:
- Growth Factors & Cytokines
Description
| Product Name: | Human Myostatin Recombinant Protein |
| Product Code: | RPPB0778 |
| Size: | 10µg |
| Species: | Human |
| Target: | Myostatin |
| Synonyms: | GDF-8, MSTN, Growth/Differentiation Factor 8,MSTN Muscle Hypertrophy. |
| Source: | Escherichia Coli |
| Physical Appearance: | Filtered white lyophilized (freeze-dried) powder. |
| Formulation: | Filtered (0.4�m) and lyophilized from 0.5mg/ml in 0.05M acetate buffer, pH 4.5. |
| Solubility: | Add 0.1M Acetate buffer pH-4 to prepare a working stock solution of approximately 0.5 mg/mL and let the lyophilized pellet dissolve completely. For conversion into higher pH value, we recommend intensive dilution by relevant buffer to a concentration of 10?g/ml. In higher concentrations the solubility of this antigen is limited. |
| Stability: | Store lyophilized protein at -20°C. Aliquot the product after reconstitution to avoid repeated freezing/thawing cycles. Reconstituted protein can be stored at 4°C for a limited period of time; it does not show any change after two weeks at 4°C. |
| Purity: | Greater than 95% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MRGSHHHHHH GMASMTGGQQ MGRDLYDDDD KDPSSRSAVR SRRDFGLDCD EHSTESRCCR YPLTVDFEAFGWDWIIAPKR YKANYCSGEC EFVFLQKYPH THLVHQANPR GSAGPCCTPT KMSPINMLYF NGKEQIIYGKIPAMVVDRCG CS |
Myostatin (GDF-8) is expressed uniquely in human skeletal muscle as a 12 kDa mature glycoprotein consisting of 113 amino acid residues and secreted into plasma.
Total 152AA. M.W. 16.7kDa (calculated). N-terminal His-tag and spacer (43AA � highlighted). The AA sequence of the human myostatin part of the fusion protein is corresponding to the UniProtKB/Swiss-Prot entry O14793.
| UniProt Protein Function: | MSTN: Acts specifically as a negative regulator of skeletal muscle growth. Defects in MSTN are the cause of muscle hypertrophy (MSLHP). MSLHP is a condition characterized by increased muscle bulk and strength. Affected individuals are exceptionally strong. Belongs to the TGF-beta family. |
| UniProt Protein Details: | Protein type:Secreted; Secreted, signal peptide Chromosomal Location of Human Ortholog: 2q32.2 Cellular Component: extracellular space Molecular Function:cytokine activity; identical protein binding; protein binding; receptor binding; transforming growth factor beta receptor binding Biological Process: cell development; muscle development; muscle maintenance; negative regulation of myoblast differentiation; negative regulation of protein kinase B signaling cascade; negative regulation of skeletal muscle growth; positive regulation of transcription, DNA-dependent; regulation of apoptosis; regulation of MAPKKK cascade Disease: Muscle Hypertrophy |
| UniProt Code: | O14793 |
| NCBI GenInfo Identifier: | 4885259 |
| NCBI Gene ID: | 2660 |
| NCBI Accession: | NP_005250.1 |
| UniProt Secondary Accession: | O14793,Q6B0H2, A1C2J7, A1C2K0, |
| UniProt Related Accession: | O14793 |
| Molecular Weight: | 42,750 Da |
| NCBI Full Name: | growth/differentiation factor 8 preproprotein |
| NCBI Synonym Full Names: | myostatin |
| NCBI Official Symbol: | MSTN�� |
| NCBI Official Synonym Symbols: | GDF8; MSLHP�� |
| NCBI Protein Information: | growth/differentiation factor 8 |
| UniProt Protein Name: | Growth/differentiation factor 8 |
| UniProt Synonym Protein Names: | Myostatin |
| Protein Family: | Growth/differentiation factor |
| UniProt Gene Name: | MSTN�� |
| UniProt Entry Name: | GDF8_HUMAN |
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