Human Myostatin Propeptide Recombinant Protein (RPPB0780)
- SKU:
- RPPB0780
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- O14793
- Research Area:
- Growth Factors & Cytokines
Description
| Product Name: | Human Myostatin Propeptide Recombinant Protein |
| Product Code: | RPPB0780 |
| Size: | 25µg |
| Species: | Human |
| Target: | Myostatin Propeptide |
| Synonyms: | GDF-8, MSTN, Growth Differentiation Factor 8, MSTN Muscle Hypertrophy. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered white lyophilized (freeze-dried) powder. |
| Formulation: | Lyophilized with no additives. |
| Solubility: | It is recommended to reconstitute the lyophilized Myostatin Propeptide in sterile 20mM HCl at 0.1mg/ml, which can then be further diluted to other aqueous solutions.� |
| Stability: | Store lyophilized protein at -20°C. Aliquot the product after reconstitution to avoid repeated freezing/thawing cycles. Reconstituted protein can be stored at 4°C for a limited period of time. |
| Purity: | Greater than 95.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MNENSEQKE NVEKEGLCNA CTWRQNTKSS RIEAIKIQIL SKLRLETAPN ISKDVIRQLL PKAPPLRELI DQYDVQRDDS SDGSLEDDDY HATTETIITM PTESDFLMQV DGKPKCCFFK FSSKIQYNKV VKAQLWIYLR PVETPTTVFV QILRLIKPMK DGTRYTGIRS LKLDMNPGTG IWQSIDVKTV LQNWLKQPES NLGIEIKALD ENGHDLAVTF PGPGEDGLNP FLEVKVTDTP KRSRR |
| Biological Activity: | The protein has full biological activity when compared to a standard. The activity is determined by its ability to inhibit 50ng/ml of Myostatin on MPC-11 cells and is typically 0.13-0.2 ?g/ml. |
Myostatin (GDF-8), a member of the TGFbeta superfamily, is a potent and specific negative regulator of skeletal muscle mass. In serum, myostatin circulates as part of a latent complex containing myostatin propeptide and/or follistatin-related gene. The myostatin propeptide is known to bind and inhibit myostatin in vitro. This interaction is relevant in vivo, with a majority (>70%) of myostatin in serum bound to its propeptide. The myostatin propeptide is negative regulator of myostatin in vivo.
Recombinant Human Myostatin Propeptide is a 27.8kDa protein containing 244 amino acid residues of the human Myostatin Propeptide.
| UniProt Protein Function: | MSTN: Acts specifically as a negative regulator of skeletal muscle growth. Defects in MSTN are the cause of muscle hypertrophy (MSLHP). MSLHP is a condition characterized by increased muscle bulk and strength. Affected individuals are exceptionally strong. Belongs to the TGF-beta family. |
| UniProt Protein Details: | Protein type:Secreted; Secreted, signal peptide Chromosomal Location of Human Ortholog: 2q32.2 Cellular Component: extracellular space Molecular Function:cytokine activity; identical protein binding; protein binding; receptor binding; transforming growth factor beta receptor binding Biological Process: cell development; muscle development; muscle maintenance; negative regulation of myoblast differentiation; negative regulation of protein kinase B signaling cascade; negative regulation of skeletal muscle growth; positive regulation of transcription, DNA-dependent; regulation of apoptosis; regulation of MAPKKK cascade Disease: Muscle Hypertrophy |
| UniProt Code: | O14793 |
| NCBI GenInfo Identifier: | 4885259 |
| NCBI Gene ID: | 2660 |
| NCBI Accession: | NP_005250.1 |
| UniProt Secondary Accession: | O14793,Q6B0H2, A1C2J7, A1C2K0, |
| UniProt Related Accession: | O14793 |
| Molecular Weight: | 42,750 Da |
| NCBI Full Name: | growth/differentiation factor 8 preproprotein |
| NCBI Synonym Full Names: | myostatin |
| NCBI Official Symbol: | MSTN�� |
| NCBI Official Synonym Symbols: | GDF8; MSLHP�� |
| NCBI Protein Information: | growth/differentiation factor 8 |
| UniProt Protein Name: | Growth/differentiation factor 8 |
| UniProt Synonym Protein Names: | Myostatin |
| Protein Family: | Growth/differentiation factor |
| UniProt Gene Name: | MSTN�� |
| UniProt Entry Name: | GDF8_HUMAN |
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