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Human Myoglobin His Recombinant Protein (RPPB4045)

SKU:
RPPB4045
Product Type:
Recombinant Protein
Species:
Human
Uniprot:
P02144
€309
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Description

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Product Name:Human Myoglobin His Recombinant Protein
Product Code:RPPB4045
Size:20µg
Species:Human
Target:Myoglobin His
Synonyms:PVALB, MGC13548.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered clear solution.
Formulation:The MB protein solution (1mg/1ml) is formulated in 20mM Tris-HCl buffer (pH8.0)1mM DTT, 100mM NaCl and 20% glycerol.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks.�Store, frozen at -20°C for longer periods of time.Please avoid freeze thaw cycles.
Purity:Greater than 90% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MGLSDGEWQL VLNVWGKVEA DIPGHGQEVL IRLFKGHPET LEKFDKFKHL KSEDEMKASE DLKKHGATVL TALGGILKKK GHHEAEIKPL AQSHATKHKI PVKYLEFISE CIIQVLQSKH PGDFGADAQG AMNKALELFR KDMASNYKEL GFQG

Myoglobin, mitochondrial precursor is a cytosolic oxygen-binding protein in charge of the storage and diffusion of oxygen within myocytes. The largest expression of MB is in the skeletal and cardiac muscle. MB operates in various functions in muscular oxygen supply, such as oxygen storage, facilitated diffusion, and myoglobin-mediated oxidative phosphorylation.

MB produced in E.Coli is a single, non-glycosylated polypeptide chain containing 174 amino acids (1-154a.a.) and having a molecular mass of 19.3kDa.MB is fused to a 20 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

UniProt Protein Function:MB: Serves as a reserve supply of oxygen and facilitates the movement of oxygen within muscles. Belongs to the globin family.
UniProt Protein Details:

Protein type:Carrier

Chromosomal Location of Human Ortholog: 22q13.1

Molecular Function:iron ion binding; heme binding; oxygen binding; oxygen transporter activity

Biological Process: slow-twitch skeletal muscle fiber contraction; response to hydrogen peroxide; oxygen transport; heart development; response to hormone stimulus; brown fat cell differentiation; response to hypoxia; enucleate erythrocyte differentiation

NCBI Summary:This gene encodes a member of the globin superfamily and is expressed in skeletal and cardiac muscles. The encoded protein is a haemoprotein contributing to intracellular oxygen storage and transcellular facilitated diffusion of oxygen. At least three alternatively spliced transcript variants encoding the same protein have been reported. [provided by RefSeq, Jul 2008]
UniProt Code:P02144
NCBI GenInfo Identifier:127661
NCBI Gene ID:4151
NCBI Accession:P02144.2
UniProt Secondary Accession:P02144,Q52H51, Q5THY7,
UniProt Related Accession:P02144
Molecular Weight:17,184 Da
NCBI Full Name:Myoglobin
NCBI Synonym Full Names:myoglobin
NCBI Official Symbol:MB��
NCBI Official Synonym Symbols:PVALB; myoglobgin��
NCBI Protein Information:myoglobin
UniProt Protein Name:Myoglobin
Protein Family:Myoglobin
UniProt Gene Name:MB��
UniProt Entry Name:MYG_HUMAN

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