Human MYL2 Recombinant Protein (RPPB4033)
- SKU:
- RPPB4033
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- P10916
Description
| Product Name: | Human MYL2 Recombinant Protein |
| Product Code: | RPPB4033 |
| Size: | 25µg |
| Species: | Human |
| Target: | MYL2 |
| Synonyms: | MLC2, CMH10, MYL-2, Myosin regulatory light chain 2, MYOSIN LIGHT CHAIN REGULATORY VENTRICULAR, DKFZp779C0562, MYL2, MLC-2v, MLC-2. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile filtered colorless solution. |
| Formulation: | MYL2 solution containing 20mM Tris pH-8, 40% glycerol and 5mM CaCl2. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 95.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MAPKKAKKRA GGANSNVFSM FEQTQIQEFK EAFTIMDQNR DGFIDKNDLR DTFAALGRVN VKNEEIDEMI KEAPGPINFT VFLTMFGEKL KGADPEETIL NAFKVFDPEG KGVLKADYVR EMLTTQAERF SKEEVDQMFA AFPPDVTGNL DYKNLVHIIT HGEEKD |
MYL2 regulatory light chain is associated with cardiac myosin beta (or slow) heavy chain. Ca+ activates the phosphorylation of regulatory light chain that in turn activates contraction. Mutations in this MYL2 gene are related with mid-left ventricular chamber type hypertrophic cardiomyopathy. MYL2 is an essential protein that plays a role in the regulation of myosin ATPase activity in smooth muscle. MYL2 phosphorylation is regulated by ROCK and MLC kinase and is involved in platelet biogenesis by controlling proplatelet formation and fragmentation.
MYL2 Human Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 186 amino acids (1-166) and having a molecular mass of 20.9 kDa. MYL2 is fused to a 20 amino acid His Tag fused at N-terminus and purified by proprietary chromatographic techniques.
| UniProt Protein Function: | MRLC2V: myosin regulatory light chain 2, ventricular/cardiac muscle isoform. Ca+ triggers the phosphorylation of regulatory light chain that in turn triggers contraction. Mutations in MYL2 are associated with mid-left ventricular chamber type hypertrophic cardiomyopathy. |
| UniProt Protein Details: | Protein type:Contractile Chromosomal Location of Human Ortholog: 12q24.11 Cellular Component: sarcomere; cytoskeleton; myofibril; cytosol; myosin complex; A band; actin cytoskeleton Molecular Function:actin monomer binding; protein binding; structural constituent of muscle; calcium ion binding; myosin heavy chain binding Biological Process: muscle cell fate specification; heart contraction; regulation of striated muscle contraction; ventricular cardiac muscle morphogenesis; cardiac myofibril assembly; negative regulation of cell growth; muscle fiber development; muscle filament sliding; cardiac muscle contraction; post-embryonic development Disease: Cardiomyopathy, Familial Hypertrophic, 10 |
| NCBI Summary: | Thus gene encodes the regulatory light chain associated with cardiac myosin beta (or slow) heavy chain. Ca+ triggers the phosphorylation of regulatory light chain that in turn triggers contraction. Mutations in this gene are associated with mid-left ventricular chamber type hypertrophic cardiomyopathy. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P10916 |
| NCBI GenInfo Identifier: | 6166556 |
| NCBI Gene ID: | 4633 |
| NCBI Accession: | P10916.3 |
| UniProt Secondary Accession: | P10916,Q16123, |
| UniProt Related Accession: | P10916 |
| Molecular Weight: | 166 |
| NCBI Full Name: | Myosin regulatory light chain 2, ventricular/cardiac muscle isoform |
| NCBI Synonym Full Names: | myosin, light chain 2, regulatory, cardiac, slow |
| NCBI Official Symbol: | MYL2�� |
| NCBI Official Synonym Symbols: | MLC2; CMH10�� |
| NCBI Protein Information: | myosin regulatory light chain 2, ventricular/cardiac muscle isoform; MLC-2; MLC-2v; RLC of myosin; myosin light chain 2; regulatory light chain of myosin; cardiac ventricular myosin light chain 2; slow cardiac myosin regulatory light chain 2; myosin, light polypeptide 2, regulatory, cardiac, slow |
| UniProt Protein Name: | Myosin regulatory light chain 2, ventricular/cardiac muscle isoform |
| Protein Family: | Myosin regulatory |
| UniProt Gene Name: | MYL2�� |
| UniProt Entry Name: | MLRV_HUMAN |
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