Human MYL12A Recombinant Protein (RPPB4031)
- SKU:
- RPPB4031
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- P19105
Description
| Product Name: | Human MYL12A Recombinant Protein |
| Product Code: | RPPB4031 |
| Size: | 20µg |
| Species: | Human |
| Target: | MYL12A |
| Synonyms: | Myosin regulatory light chain 12A, MLC-2B, Myosin RLC, Myosin regulatory light chain 2 nonsarcomeric, Myosin regulatory light chain MRLC3, MYL12A, MLCB, MRLC3, RLC, MRCL3, MYL2B. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | MYL12A protein solution (0.25mg/ml) containing 20mM Tris-HCl buffer (pH8.0), 20% glycerol and 1mM DTT. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 90.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MGSHMSSKRT KTKTKKRPQR ATSNVFAMFD QSQIQEFKEA FNMIDQNRDG FIDKEDLHDM LASLGKNPTD EYLDAMMNEA PGPINFTMFL TMFGEKLNGT DPEDVIRNAF ACFDEEATGT IQEDYLRELL TTMGDRFTDE EVDELYREAP IDKKGNFNYI EFTRILKHGA KDKDD |
Myosin regulatory light chain 12A (MYL12A) has a vital role in regulation of both smooth muscle and nonmuscle cell contractile activity via its phosphorylation. The MYL12A protein is involved in cytokinesis, receptor capping, and cell locomotion.
MYL12A Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 195 amino acids (1-171 a.a.) and having a molecular mass of 22.4kDa.MYL12A is fused to a 24 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | MRLC3: Myosin regulatory subunit that plays an important role in regulation of both smooth muscle and nonmuscle cell contractile activity via its phosphorylation. Implicated in cytokinesis, receptor capping, and cell locomotion. Myosin is an hexamer of 2 heavy chains and 4 light chains. |
| UniProt Protein Details: | Protein type:Contractile Chromosomal Location of Human Ortholog: 18p11.31 Cellular Component: myosin II complex; stress fiber; cytosol; Z disc Molecular Function:protein binding; glutamate receptor binding; calcium ion binding Biological Process: axon guidance; regulation of cell shape; ephrin receptor signaling pathway |
| NCBI Summary: | This gene encodes a nonsarcomeric myosin regulatory light chain. This protein is activated by phosphorylation and regulates smooth muscle and non-muscle cell contraction. This protein may also be involved in DNA damage repair by sequestering the transcriptional regulator apoptosis-antagonizing transcription factor (AATF)/Che-1 which functions as a repressor of p53-driven apoptosis. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 8.[provided by RefSeq, Dec 2014] |
| UniProt Code: | P19105 |
| NCBI GenInfo Identifier: | 127169 |
| NCBI Gene ID: | 10627 |
| NCBI Accession: | P19105.2 |
| UniProt Secondary Accession: | P19105,Q53X45, |
| UniProt Related Accession: | P19105 |
| Molecular Weight: | 171 |
| NCBI Full Name: | Myosin regulatory light chain 12A |
| NCBI Synonym Full Names: | myosin, light chain 12A, regulatory, non-sarcomeric |
| NCBI Official Symbol: | MYL12A�� |
| NCBI Official Synonym Symbols: | MLCB; MRCL3; MRLC3; MYL2B; MLC-2B; HEL-S-24�� |
| NCBI Protein Information: | myosin regulatory light chain 12A; myosin RLC; myosin regulatory light chain 3; epididymis secretory protein Li 24; myosin regulatory light chain MRLC3; myosin regulatory light chain 2, nonsarcomeric; myosin, light polypeptide, regulatory, non-sarcomeric |
| UniProt Protein Name: | Myosin regulatory light chain 12A |
| UniProt Synonym Protein Names: | Epididymis secretory protein Li 24; HEL-S-24; MLC-2B; Myosin RLC; Myosin regulatory light chain 2, nonsarcomeric; Myosin regulatory light chain MRLC3 |
| Protein Family: | C-type mannose receptor |
| UniProt Gene Name: | MYL12A�� |
| UniProt Entry Name: | ML12A_HUMAN |
