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Human MRGX1-Strep full length protein-synthetic nanodisc (HDFP1075)

SKU:
HDFP1075
Size:
10μg
Target:
MRGX1
Tag:
C-Flag&Strep Tag
Expression Host:
HEK293
Conjugate:
Unconjugated
$1,499

Description

system_update_altDatasheetsystem_update_altMSDS
Product Name:Nanodisc Human MRGX1-Strep Protein
SKU:HDFP1075
Size:10μg
Target:MRGX1
Tag:C-Flag&Strep Tag
Expression Host:HEK293
Conjugate:Unconjugated
Synonyms:GPCR, MGRG2, MRGX1, SNSR4
Protein Families:GPCR, Transmembrane, Druggable Genome.
Protein Description:Human MRGX1-Strep full length protein-synthetic nanodisc
Molecular Weight:The human full length MRGX1-Strep protein has a MW of 36.3 kDa

Orphan receptor. Probably involved in the function of nociceptive neurons. May regulate nociceptor function and/or development, including the sensation or modulation of pain. Potently activated by enkephalins including BAM22 (bovine adrenal medulla peptide 22) and BAM (8-22)(PubMed:26582731). BAM22 is the most potent compound and evoked a large and dose-dependent release of intracellular calcium in stably transfected cells. G(alpha)q proteins are involved in the calcium-signaling pathway. Activated by the antimalarial drug, chloroquine. May mediate chloroquine-induced itch, in a histamine-independent manner.[UniProtKB/Swiss-Prot Function]

Uniprot ID:Q96LB2
Formulation & Reconstitution:Lyophilized from nanodisc solubilization buffer (20 mM Tris-HCl, 150 mM NaCl, pH 8.0). Normally 5% – 8% trehalose is added as protectants before lyophilization. Please see Certificate of Analysis for specific instructions. Do not use solvents with a pH below 6.5 or those containing high concentrations of divalent metal ions (greater than 5 mM) in subsequent experiments.
Storage & Shipping:Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.
Usage:Research use only

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