The CD47 Monoclonal Antibody PE Conjugated (MIAP410) offered by Assay Genie (product code AGEL0670) is a cutting-edge tool for researchers studying CD47 expression in human, mouse, and rat samples. CD47, a cell surface protein involved in various cellular processes including immune evasion and cell signaling, is a key player in cancer biology and immunology.This monoclonal antibody, conjugated to phycoerythrin (PE) for fluorescent detection, allows for precise and sensitive detection of CD47 in flow cytometry and immunofluorescence applications. With its high specificity and affinity for CD47, researchers can confidently analyze CD47 expression levels in a wide range of cell types and tissues.
The CD47 Monoclonal Antibody PE Conjugated (MIAP410) is a versatile tool for investigating the role of CD47 in cancer progression, immune response modulation, and potential therapeutic targeting. With its reliability and consistency, this antibody is essential for advancing research in oncology, immunotherapy, and related fields.Researchers can trust Assay Genie's CD47 Monoclonal Antibody PE Conjugated (MIAP410) to provide reliable and reproducible results, making it a valuable asset for studies aiming to unravel the complex functions of CD47 in health and disease.
Each lot of this antibody is quality control tested by flow cytometric analysis. The amount of the reagent is suggested to be used 5 µL of antibody per test (million cells in 100 µL staining volume or per 100 µL of whole blood). Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use.
Spectrum:
Swissprot:
Q08722 Q61735 P97829
Gene ID:
961,16423,29364
Storage Buffer:
Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Stability & Storage:
Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:
CD47, also known as Integrin-Associated Protein (IAP), is a membrane protein of about 50 kD with an IgV-like extracelluluar domain, a five membrane-spanning segment and a short terminal cytoplasmic region. It is widely expressed on many cell types and often associated with beta 3 integrins. It has been reported that CD47 functions as a self marker. Red cells lacking CD47 were rapidly cleared from the bloodstream by splenic macrophages. By binding to SIRPα, CD47 controls hemostatic innate immune functions, such as phagocytosis and cell trafficking.