Human MORF4L1 Recombinant Protein (RPPB3990)
- SKU:
- RPPB3990
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- Q9UBU8
Description
| Product Name: | Human MORF4L1 Recombinant Protein |
| Product Code: | RPPB3990 |
| Size: | 20µg |
| Species: | Human |
| Target: | MORF4L1 |
| Synonyms: | Mortality factor 4-like protein 1, MORF-related gene 15 protein, Protein MSL3-1, Transcription factor-like protein MRG15, MORF4L1, MRG15, FWP006, HSPC008, HSPC061, PP368, Eaf3, MEAF3, S863-6, HsT17725, MORFRG15. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | MORF4L1 protein solution (1mg/ml) containing 20mM Tris-HCl buffer (pH8.0), 30% glycerol, 0.15M NaCl and 1mM DTT. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 85.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MGSHMAPKQD PKPKFQEGER VLCFHGPLLY EAKCVKVAIK DKQVKYFIHY SGWNKNWDEW VPESRVLKYV DTNLQKQREL QKANQEQYAE GKMRGAAPGK KTSGLQQKNV EVKTKKNKQK TPGNGDGGST SETPQPPRKK RARVDPTVEN EETFMNRVEV KVKIPEELKP WLVDDWDLIT RQKQLFYLPA KKNVDSILED YANYKKSRGN TDNKEYAVNE VVAGIKEYFN VMLGTQLLYK FERPQYAEIL ADHPDAPMSQ VYGAPHLLRL FVRIGAMLAY TPLDEKSLAL LLNYLHDFLK YLAKNSATLF SASDYEVAPP EYHRKAV |
Mortality factor 4-like protein 1 (MORF4L1) is a member of the MRG family. MORF4L1 is a component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes mostly by acetylation of nucleosomal histones H4 and H2A. MORF4L1 is a transcription factor expressed in various human tissues, and its orthologs have been found in many other eukaryotes which comprise the MRG protein family. The C-terminal part of MORF4L1 forms a conserved MRG domain that is involved in interactions with the tumor suppressor protein retinoblastoma and a nucleoprotein.
MORF4L1 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 347 amino acids (1-323 a.a) and having a molecular mass of 39.8kDa.MORF4L1 is fused to a 24 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | MORF4L1: Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. The NuA4 complex ATPase and helicase activities seem to be, at least in part, contributed by the association of RUVBL1 and RUVBL2 with EP400. NuA4 may also play a direct role in DNA repair when directly recruited to sites of DNA damage. Also component of the mSin3A complex which acts to repress transcription by deacetylation of nucleosomal histones. Required for homologous recombination repair (HRR) and resistance to mitomycin C (MMC). Involved in the localization of PALB2, BRCA2 and RAD51, but not BRCA1, to DNA-damage foci. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Transcription, coactivator/corepressor Chromosomal Location of Human Ortholog: 15q24 Cellular Component: nucleoplasm; NuA4 histone acetyltransferase complex; Sin3 complex Molecular Function:protein binding; protein N-terminus binding; chromatin binding Biological Process: cell proliferation; establishment and/or maintenance of chromatin architecture; regulation of transcription, DNA-dependent; transcription, DNA-dependent; regulation of growth; histone deacetylation; double-strand break repair via homologous recombination |
| UniProt Code: | Q9UBU8 |
| NCBI GenInfo Identifier: | 59803121 |
| NCBI Gene ID: | 10933 |
| NCBI Accession: | Q9UBU8.2 |
| UniProt Secondary Accession: | Q9UBU8,O95899, Q5QTS1, Q6NVX8, Q86YT7, Q9HBP6, Q9NSW5 B4DKN6, B7Z6R1, D3DW88, |
| UniProt Related Accession: | Q9UBU8 |
| Molecular Weight: | 362 |
| NCBI Full Name: | Mortality factor 4-like protein 1 |
| NCBI Synonym Full Names: | mortality factor 4 like 1 |
| NCBI Official Symbol: | MORF4L1�� |
| NCBI Official Synonym Symbols: | Eaf3; MEAF3; MRG15; FWP006; S863-6; HsT17725; MORFRG15�� |
| NCBI Protein Information: | mortality factor 4-like protein 1; protein MSL3-1; MORF-related gene 15 protein; Esa1p-associated factor 3 homolog; MORF-related gene on chromosome 15; transcription factor-like protein MRG15 |
| UniProt Protein Name: | Mortality factor 4-like protein 1 |
| UniProt Synonym Protein Names: | MORF-related gene 15 protein; Protein MSL3-1; Transcription factor-like protein MRG15 |
| Protein Family: | Mortality factor 4-like protein |
| UniProt Gene Name: | MORF4L1�� |
| UniProt Entry Name: | MO4L1_HUMAN |
