The Human Monkey CD154 Monoclonal Antibody (Biotin Conjugated) is a valuable tool for researchers studying CD154, a protein involved in immune responses and immune regulation. This monoclonal antibody, labeled with biotin for added versatility, specifically targets CD154 in both human and monkey samples, providing reliable results in various assays.CD154, also known as CD40 ligand, is a key molecule in immune system activation, playing a crucial role in the regulation of immune responses. By targeting CD154 with this high-quality antibody, researchers can detect and analyze its expression in different cell types, making it ideal for studies in immunology, vaccine development, and autoimmune diseases.
The CD154 Monoclonal Antibody offers a precise and sensitive tool for investigating the mechanisms underlying immune activation and regulation. Its application extends to research areas such as transplantation, infectious diseases, and inflammatory disorders, where understanding CD154 function is essential for developing targeted therapies and interventions.
Each lot of this antibody is quality control tested by flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 1.0 µg per 106 cells in 100 µL volume or 100 µL of whole blood. It is recommended that the reagent be titrated for optimal performance for each application.
Swissprot:
P29965
Gene ID:
959
Storage Buffer:
Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Stability & Storage:
Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:
CD154 (CD40 ligand) is also known as CD40L, gp39, TRAP and T-BAM. CD40 ligand is a 32-39 kD type II transmembrane glycoprotein. It is a member of the TNF superfamily and is expressed on activated T cells. It has been reported to be important for B cell costimulation following binding of its receptor, CD40. Additionally, binding of CD40L to CD40 on B cells promotes the secretion of immunoglobulin and Ig isotype switching. CD40L is also involved in the regulation of cytokine production by T cells.
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