Human MOCS2 Recombinant Protein (RPPB3987)
- SKU:
- RPPB3987
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- O96033
Description
| Product Name: | Human MOCS2 Recombinant Protein |
| Product Code: | RPPB3987 |
| Size: | 10µg |
| Species: | Human |
| Target: | MOCS2 |
| Synonyms: | Molybdenum Cofactor Synthesis 2, Molybdopterin Synthase Sulfur Carrier Subunit, Molybdenum Cofactor Biosynthesis Protein E, MPT Synthase Large Subunit, Molybdopterin Synthase Catalytic Subunit, Molybdenum Cofactor Synthesis Protein 2 Large Subunit, Molybdenum Cofactor Synthesis Protein 2 Small Subunit, Molybdenum Cofactor Synthesis Protein 2A, Molybd enum Cofactor Synthesis Protein 2B, Sulfur Carrier Protein MOCS2A, MCBPE, MOCO1, MOCO1-A, MOCO1-B, MOCS2A, MOCS2B, MPTS, EC 2.8.1.12. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | The MOCS2 solution (0.25mg/1ml) contains 20mM Tris-HCl buffer (pH 8.0), 0.15M NaCl, 1mM DTT and 50% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 90% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MRGSHHHHHH GMASMTGGQQ MGRDLYDDDD KDRWGSMSSL EISSSCFSLE TKLPLSPPLV EDSAFEPSRK DMDEVEEKSK DVINFTAEKL SVDEVSQLVI SPLCGAISLF VGTTRNNFEG KKVISLEYEA YLPMAENEVR KICSDIRQKW PVKHIAVFHR LGLVPVSEAS IIIAVSSAHR AASLEAVSYA IDTLKAKVPI WKKEIYEESS TWKGNKECFW ASNS |
Molybdenum Cofactor Synthesis 2 (MOCS2) is a heterotetrameric synthase comprised of 2 small (MOCS2A) and 2 large (MOCS2B) subunits. Both the large and small subunits of molybdopterin synthase are encoded from the MOCS2 gene by overlapping open reading frames. MOCS2 operates in the second step of the molybdenum cofactor or molybdopterin (MPT) synthesis. MOCS2 catalyzes the formation of MPT from precursor Z by incorporating a dithiolene functional group.
MOCS2 Human Recombinant produced in E. coli is a single polypeptide chain containing 224 amino acids (1-188) and having a molecular mass of 25.0 kDa.MOCS2 is fused to a 36 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | Catalytic subunit of the molybdopterin synthase complex, a complex that catalyzes the conversion of precursor Z into molybdopterin. Acts by mediating the incorporation of 2 sulfur atoms from thiocarboxylated MOCS2A into precursor Z to generate a dithiolene group. |
| NCBI Summary: | Eukaryotic molybdoenzymes use a unique molybdenum cofactor (MoCo) consisting of a pterin, termed molybdopterin, and the catalytically active metal molybdenum. MoCo is synthesized from precursor Z by the heterodimeric enzyme molybdopterin synthase. The large and small subunits of molybdopterin synthase are both encoded from this gene by overlapping open reading frames. The proteins were initially thought to be encoded from a bicistronic transcript. They are now thought to be encoded from monocistronic transcripts. Alternatively spliced transcripts have been found for this locus that encode the large and small subunits. [provided by RefSeq, Jul 2008] |
| UniProt Code: | O96033 |
| NCBI GenInfo Identifier: | 4758732 |
| NCBI Gene ID: | 4338 |
| NCBI Accession: | NP_004522 |
| UniProt Secondary Accession: | O96033,Q6IAI3, |
| UniProt Related Accession: | O96007,O96033 |
| Molecular Weight: | 25 kDa (224aa) confirmed by MALDI-TOF |
| NCBI Full Name: | molybdopterin synthase catalytic subunit large subunit MOCS2B |
| NCBI Synonym Full Names: | molybdenum cofactor synthesis 2 |
| NCBI Official Symbol: | MOCS2�� |
| NCBI Official Synonym Symbols: | MPTS; MCBPE; MOCO1; MOCODB�� |
| NCBI Protein Information: | molybdopterin synthase catalytic subunit; molybdopterin synthase sulfur carrier subunit |
| UniProt Protein Name: | Molybdopterin synthase catalytic subunit |
| UniProt Synonym Protein Names: | MOCO1-B; Molybdenum cofactor synthesis protein 2 large subunit |
| UniProt Gene Name: | MOCS2�� |
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