Human MOAP1 Recombinant Protein (RPPB3984)
- SKU:
- RPPB3984
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- Q96BY2
Description
| Product Name: | Human MOAP1 Recombinant Protein |
| Product Code: | RPPB3984 |
| Size: | 20µg |
| Species: | Human |
| Target: | MOAP1 |
| Synonyms: | ModulatorOf Apoptosis 1, MAP1, PNMA4, Paraneoplastic Ma Antigen Family Member 4, ParaneoplasticAntigen Ma4, MAP-1, Paraneoplastic Antigen Like 4. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered clear solution. |
| Formulation: | MOAP1 protein solution (0.5mg/ml) containing 20mMTris-HCl buffer (pH 8.0), 0.4M Urea and 10% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please avoid freeze thaw cycles. |
| Purity: | Greaterthan 85% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MGSMTLRLLE DWCRGMDMNP RKALLIAGIS QSCSVAEIEE ALQAGLAPLG EYRLLGRMFR RDENRKVALV GLTAETSHAL VPKEIPGKGG IWRVIFKPPD PDNTFLSRLN EFLAGEGMTV GELSRALGHE NGSLDPEQGM IPEMWAPMLA QALEALQPALQCLKYKKLRV FSGRESPEPG EEEFGRWMFH TTQMIKAWQV PDVEKRRRLL ESLRGPALDV IRVLKINNPL ITVDECLQAL EEVFGVTDNP RELQVKYLTT YQKDEEKLSA YVLRLEPLLQ KLVQRGAIER DAVNQARLDQ VIAGAVHKTI RRELNLPEDG PAPGFLQLLV LIKDYEAAEEEEALLQAILE GNFT |
Modulatorof apoptosis 1 (MOAP1), is a member of the PNMA family and contains one BH3-like domainand one RASSF1-binding domain. MOAP1 was recognized by its interaction withapoptosis regulator BAX protein. MOAP1 includes a Bcl-2 homology 3 (BH3)-likemotif, which is essential for the association with BAX. In addition, once overexpressed MOAP1 mediates caspase-dependent apoptosis.
MOAP1 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 374 amino acids (1-351a.a) and having a molecular mass of 41.9kDa.MOAP1 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | MOAP1: Required for death receptor-dependent apoptosis. When associated with RASSF1, promotes BAX conformational change and translocation to mitochondrial membranes in response to TNF and TNFSF10 stimulation. Belongs to the PNMA family. |
| UniProt Protein Details: | Chromosomal Location of Human Ortholog: 14q32 Cellular Component: mitochondrial outer membrane; mitochondrion; cytoplasm; cytosol Molecular Function:protein binding; ubiquitin protein ligase binding Biological Process: DNA damage response, signal transduction resulting in induction of apoptosis; induction of apoptosis via death domain receptors; protein insertion into mitochondrial membrane during induction of apoptosis; positive regulation of apoptosis |
| NCBI Summary: | The protein encoded by this gene was identified by its interaction with apoptosis regulator BAX protein. This protein contains a Bcl-2 homology 3 (BH3)-like motif, which is required for the association with BAX. When overexpressed, this gene has been shown to mediate caspase-dependent apoptosis. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q96BY2 |
| NCBI GenInfo Identifier: | 19923584 |
| NCBI Gene ID: | 64112 |
| NCBI Accession: | NP_071434.2 |
| UniProt Secondary Accession: | Q96BY2,Q9H833, Q9HAS1, B2RDF6, |
| UniProt Related Accession: | Q96BY2 |
| Molecular Weight: | 39,513 Da |
| NCBI Full Name: | modulator of apoptosis 1 |
| NCBI Synonym Full Names: | modulator of apoptosis 1 |
| NCBI Official Symbol: | MOAP1�� |
| NCBI Official Synonym Symbols: | MAP-1; PNMA4�� |
| NCBI Protein Information: | modulator of apoptosis 1; MAP1; paraneoplastic Ma antigen family member 4; paraneoplastic antigen Ma4; paraneoplastic antigen like 4 |
| UniProt Protein Name: | Modulator of apoptosis 1 |
| UniProt Synonym Protein Names: | Paraneoplastic antigen Ma4 |
| Protein Family: | Modulator of apoptosis |
| UniProt Gene Name: | MOAP1�� |
| UniProt Entry Name: | MOAP1_HUMAN |
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