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Human MMP28 Recombinant Protein (RPPB1972)

SKU:
RPPB1972
Product Type:
Recombinant Protein
Species:
Human
Uniprot:
Q9H239
Research Area:
Enzymes
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Description

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Product Name:Human MMP28 Recombinant Protein
Product Code:RPPB1972
Size:20µg
Species:Human
Target:MMP28
Synonyms:EPILYSIN, MM28, MMP-28, MMP25, Matrix metalloproteinase-28, MMP28.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered colorless solution.
Formulation:The MMP28 solution (1mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 0.4M Urea and 10% glycerol.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Avoid multiple freeze-thaw cycles.
Purity:Greater than 90% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MGSFAKQGNK WYKQHLSYRL VNWPEHLPEP AVRGAVRAAF QLWSNVSALE FWEAPATGPA DIRLTFFQGD HNDGLGNAFD GPGGALAHAF LPRRGEAHFD QDERWSLSRR RGRNLFVVLA HEIGHTLGLT HSPAPRALMA PYYKRLGRDA LLSWDDVLAV QSLYGKPLGG SVAVQLPGKL FTDFETWDSY SPQGRRPETQ GPKYCHSSFD AITVDRQQQL YIFKGSHFWE VAADGNVSEP RPLQERWVGL PPNIEAAAVS LNDGDFYFFK GGRCWRFRGP KPVWGLPQLC RAGGLPRHPD AALFFPPLRR LILFKGARYY VLARGGLQVE PYYPRSLQDW GGIPEEVSGA LPRPDGSIIF FRDDRYWRLD QAKLQATTSG RWATELPWMG CWHANSGSAL F

MMP28, which belongs to the matrix metalloproteinase (MMP) family, takes part in the breakdown of extracellular matrix for both normal physiological processes, such as embryonic development, reproduction and tissue remodeling, and disease processes, like asthma and metastasis. MMP28 is a secreted enzyme which degrades casein. MMP28 participates in tissue homeostasis and in wound repair.

MMP28 Human Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 421 amino acids (123-520a.a) and having a molecular mass of 47.3kDa. MMP28 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

UniProt Protein Function:MMP28: Can degrade casein. Could play a role in tissues homeostasis and repair. Belongs to the peptidase M10A family. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Secreted, signal peptide; Protease; EC 3.4.24.-; Secreted; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 17q12

Cellular Component: proteinaceous extracellular matrix; cytoplasm

Molecular Function:zinc ion binding; metalloendopeptidase activity; calcium ion binding

Biological Process: proteolysis

NCBI Summary:Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix for both normal physiological processes, such as embryonic development, reproduction and tissue remodeling, and disease processes, such as asthma and metastasis. This gene encodes a secreted enzyme that degrades casein. Its expression pattern suggests that it plays a role in tissue homeostasis and in wound repair. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Apr 2014]
UniProt Code:Q9H239
NCBI GenInfo Identifier:37538314
NCBI Gene ID:79148
NCBI Accession:Q9H239.2
UniProt Secondary Accession:Q9H239,Q96F04, Q96TE2,
UniProt Related Accession:Q9H239
Molecular Weight:520
NCBI Full Name:Matrix metalloproteinase-28
NCBI Synonym Full Names:matrix metallopeptidase 28
NCBI Official Symbol:MMP28��
NCBI Official Synonym Symbols:MM28; MMP25; MMP-25; MMP-28; EPILYSIN��
NCBI Protein Information:matrix metalloproteinase-28; matrix metalloprotease MMP25
UniProt Protein Name:Matrix metalloproteinase-28
UniProt Synonym Protein Names:Epilysin
Protein Family:Matrix metalloproteinase
UniProt Gene Name:MMP28��
UniProt Entry Name:MMP28_HUMAN

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