Human MMP23B Recombinant Protein (RPPB1971)
- SKU:
- RPPB1971
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- O75900
- Research Area:
- Enzymes
Description
| Product Name: | Human MMP23B Recombinant Protein |
| Product Code: | RPPB1971 |
| Size: | 20µg |
| Species: | Human |
| Target: | MMP23B |
| Synonyms: | Matrix Metallopeptidase 23B, MMP23B, MMP22, Matrix Metalloproteinase 23B, Matrix Metalloproteinase 22, Matrix Metalloproteinase In The Female Reproductive Tract, Matrix Metalloproteinase-21, Matrix Metalloproteinase-22, MIFR-1, MMP-21, MMP-22, MMP-23, MIFR, MMP23A, Matrix Metalloproteinase-23, EC 3.4.24.-, Femalysin, MMP21. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | The MMP23B solution (0.5mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 0.4M Urea and 10% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 85% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MGSYTLTPAR LRWDHFNLTY RILSFPRNLL SPRETRRALA AAFRMWSDVS PFSFREVAPE QPSDLRIGFY PINHTDCLVS ALHHCFDGPT GELAHAFFPP HGGIHFDDSE YWVLGPTRYS WKKGVWLTDL VHVAAHEIGH ALGLMHSQHG RALMHLNATL RGWKALSQDE LWGLHRLYG |
Matrix Metallopeptidase 23B (MMP23B) belongs to the matrix metalloproteinase (MMP) family, and it is section of a duplicated region of chromosome 1p36.3. MMP23B is a protease. MMP23B regulates the surface expression of some potassium channels by holding them in the endoplasmic reticulum. Members of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis.
MMP23B Human Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 199 amino acids (79-254) and having a molecular mass of 22.6kDa.MMP23B is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | MMP23B: Protease. May regulate the surface expression of some potassium channels by retaining them in the endoplasmic reticulum. Belongs to the peptidase M10A family. 3 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Membrane protein, integral; EC 3.4.24.-; Protease Chromosomal Location of Human Ortholog: 1p36.3 Cellular Component: proteinaceous extracellular matrix; endoplasmic reticulum membrane; integral to membrane; intracellular Molecular Function:zinc ion binding; metallopeptidase activity; metalloendopeptidase activity Biological Process: proteolysis; reproduction |
| NCBI Summary: | This gene (MMP23B) encodes a member of the matrix metalloproteinase (MMP) family, and it is part of a duplicated region of chromosome 1p36.3. Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. This gene belongs to the more telomeric copy of the duplicated region. [provided by RefSeq, Jul 2008] |
| UniProt Code: | O75900 |
| NCBI GenInfo Identifier: | 117949605 |
| NCBI Gene ID: | 8510 |
| NCBI Accession: | O75900.2 |
| UniProt Secondary Accession: | O75900,O75894, O75895, Q5QPQ8, Q76P96, Q7LDM6, Q7LDM7 Q9UBR9, Q9UJK8, A2AGN0, A2AGN1, |
| UniProt Related Accession: | O75900 |
| Molecular Weight: | 46,305 Da |
| NCBI Full Name: | Matrix metalloproteinase-23 |
| NCBI Synonym Full Names: | matrix metallopeptidase 23B |
| NCBI Official Symbol: | MMP23B�� |
| NCBI Official Synonym Symbols: | MIFR; MMP22; MIFR-1; MMP23A�� |
| NCBI Protein Information: | matrix metalloproteinase-23; MMP-21; MMP-22; MMP-23; femalysin; matrix metalloproteinase 22; matrix metalloproteinase 23B; matrix metalloproteinase in the female reproductive tract; matrix metalloproteinase-21; matrix metalloproteinase-22 |
| UniProt Protein Name: | Matrix metalloproteinase-23 |
| UniProt Synonym Protein Names: | Femalysin; MIFR-1; Matrix metalloproteinase-21; MMP-21; Matrix metalloproteinase-22; MMP-22 |
| UniProt Gene Name: | MMP23A�� |
| UniProt Entry Name: | MMP23_HUMAN |
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