Human MMAB Recombinant Protein (RPPB1947)
- SKU:
- RPPB1947
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- Q96EY8
- Research Area:
- Enzymes
Description
| Product Name: | Human MMAB Recombinant Protein |
| Product Code: | RPPB1947 |
| Size: | 25µg |
| Species: | Human |
| Target: | MMAB |
| Synonyms: | CBIB, Cob(I)alamin adenosyltransferase, EC 2.5.1.17. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered clear solution. |
| Formulation: | MMAB 1mg/ml protein solution contains 20mM Tris pH-7.5 & 10% glycerol. |
| Stability: | MMAB Human although stable at 4°C for 1 week, should be stored below -18°C. Please prevent freeze thaw cycles. |
| Purity: | Greater than 95.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MQSRGPQGVE DGDRPQPSSK TPRIPKIYTK TGDKGFSSTF TGERRPKDDQ VFEAVGTTDE LSSAIGFALE LVTEKGHTFA EELQKIQCTL QDVGSALATP CSSAREAHLK YTTFKAGPIL ELEQWIDKYT SQLPPLTAFI LPSGGKISSA LHFCRAVCRR AERRVVPLVQ MGETDANVAK FLNRLSDYLF TLARYAAMKE GNQEKIYKKN DPSAESEGL |
MMAB protein catalyzes the last step in the conversion of vitamin B(12) into adenosylcobalamin (AdoCbl), a vitamin B12 containing coenzyme for methylmalonyl-CoA mutase(MCM). Decreased MMAB activity leads to the inherited disorder vitamin B12 dependent methylmalonic aciduria linked to the cblB complementation group.
MMAB Recombinant Human produced in E.Coli is a single, non-glycosylated polypeptide chain containing 239 amino acids (33-250 a.a.) and having a molecular mass of 26.3 kDa. The MMAB is fused to 21 amino acid His-Tag at N-terminus and purified by proprietary chromatographic techniques.
| UniProt Protein Function: | MMAB: Defects in MMAB are the cause of methylmalonic aciduria type cblB (MMAB); also known as methylmalonic aciduria type B or vitamin B12-responsive methylmalonicaciduria of cblB complementation type. MMAB is a disorder of methylmalonate and cobalamin metabolism due to defective synthesis of adenosylcobalamin. Inheritance is autosomal recessive. Belongs to the Cob(I)alamin adenosyltransferase family. |
| UniProt Protein Details: | Protein type:Motility/polarity/chemotaxis; EC 2.5.1.17; Transferase; Cofactor and Vitamin Metabolism - porphyrin and chlorophyll Chromosomal Location of Human Ortholog: 12q24 Cellular Component: mitochondrial matrix Molecular Function:cob(I)yrinic acid a,c-diamide adenosyltransferase activity; ATP binding Biological Process: vitamin metabolic process; cobalamin biosynthetic process; cobalamin metabolic process; water-soluble vitamin metabolic process Disease: Methylmalonic Aciduria, Cblb Type |
| NCBI Summary: | This gene encodes a protein that catalyzes the final step in the conversion of vitamin B(12) into adenosylcobalamin (AdoCbl), a vitamin B12-containing coenzyme for methylmalonyl-CoA mutase. Mutations in the gene are the cause of vitamin B12-dependent methylmalonic aciduria linked to the cblB complementation group. Alternatively spliced transcript variants have been found. [provided by RefSeq, Apr 2011] |
| UniProt Code: | Q96EY8 |
| NCBI GenInfo Identifier: | 38258221 |
| NCBI Gene ID: | 326625 |
| NCBI Accession: | Q96EY8.1 |
| UniProt Secondary Accession: | Q96EY8,Q9D273, |
| UniProt Related Accession: | Q96EY8 |
| Molecular Weight: | 27388 |
| NCBI Full Name: | Corrinoid adenosyltransferase |
| NCBI Synonym Full Names: | metabolism of cobalamin associated B |
| NCBI Official Symbol: | MMAB�� |
| NCBI Official Synonym Symbols: | ATR; cob; cblB; CFAP23�� |
| NCBI Protein Information: | corrinoid adenosyltransferase |
| UniProt Protein Name: | Cob(I)yrinic acid a,c-diamide adenosyltransferase, mitochondrial |
| UniProt Synonym Protein Names: | Cob(I)alamin adenosyltransferase; Methylmalonic aciduria type B protein |
| UniProt Gene Name: | MMAB�� |
| UniProt Entry Name: | MMAB_HUMAN |
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