Human MIA Recombinant Protein (RPPB0770)
- SKU:
- RPPB0770
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- Q16674
- Research Area:
- Growth Factors & Cytokines
Description
| Product Name: | Human MIA Recombinant Protein |
| Product Code: | RPPB0770 |
| Size: | 20µg |
| Species: | Human |
| Target: | MIA |
| Synonyms: | Melanoma-derived growth regulatory protein precursor, Cartilage-derived retinoic acid-sensitive protein, CD-RAP, MIA. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered clear solution. |
| Formulation: | The MIA solution (0.25mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 0.4M Urea and 10% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 90% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MGPMPKLADR KLCADQECSH PISMAVALQD YMAPDCRFLT IHRGQVVYVF SKLKGRGRLF WGGSVQGDYY GDLAARLGYF PSSIVREDQT LKPGKVDVKT DKWDFYCQ |
The Melanoma Inhibitory protein (MIA) was identified as an inhibitor of in vitro growth of malignant melanoma cells. The protein contains a SH3 domain.�MIA acts as a potent tumor cell growth inhibitor for malignant melanoma cells and some other neuroectodermal tumors, including gliomas, in an autocrine fashion. In a study of human melanoma cell lines with different metastatic capacity MIA mRNA expression appeared to be inversely correlated with pigmentation. MIA has been shown to represent a very sensitive and specific serum marker for systemic malignant melanoma that might be useful for staging of primary melanomas, detection of progression from localized to metastatic disease during follow-up, and monitoring therapy of advanced melanomas.
MIA Human Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 128 amino acids (25-131) and having a molecular mass of 14.4 kDa.MIA is fused to a 23 amino acid His-tag at N-terminus.
| UniProt Protein Function: | MIA: Elicits growth inhibition on melanoma cells in vitro as well as some other neuroectodermal tumors, including gliomas. Belongs to the MIA/OTOR family.Protein type: Cell adhesion; Secreted, signal peptide; SecretedChromosomal Location of Human Ortholog: 19q13.2Cellular Component: extracellular spaceMolecular Function: growth factor activityBiological Process: cell proliferation |
| UniProt Protein Details: | |
| NCBI Summary: | |
| UniProt Code: | Q16674 |
| NCBI GenInfo Identifier: | 2498559 |
| NCBI Gene ID: | 8190 |
| NCBI Accession: | Q16674.1 |
| UniProt Secondary Accession: | Q16674,Q6FHV3 |
| UniProt Related Accession: | Q16674 |
| Molecular Weight: | 6,361 Da |
| NCBI Full Name: | Melanoma-derived growth regulatory protein |
| NCBI Synonym Full Names: | melanoma inhibitory activity |
| NCBI Official Symbol: | MIA�� |
| NCBI Official Synonym Symbols: | CD-RAP�� |
| NCBI Protein Information: | melanoma-derived growth regulatory protein |
| UniProt Protein Name: | Melanoma-derived growth regulatory protein |
| UniProt Synonym Protein Names: | Melanoma inhibitory activity protein |
| Protein Family: | Melanoma-derived growth regulatory protein |
| UniProt Gene Name: | MIA�� |
| UniProt Entry Name: | MIA_HUMAN |
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