Human METRNL Recombinant Protein (RPPB3964)
- SKU:
- RPPB3964
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- Q641Q3
Description
| Product Name: | Human METRNL Recombinant Protein |
| Product Code: | RPPB3964 |
| Size: | 10µg |
| Species: | Human |
| Target: | METRNL |
| Synonyms: | Meteorin-like protein, Subfatin, METRNL. |
| Source: | Escherichia Coli |
| Physical Appearance: | Filtered White lyophilized (freeze-dried) powder. |
| Formulation: | METRNL filtered (0.4 �m) and lyophilized from 0.5mg/ml in 50mM acetate buffer, 5% trehalose (w/v) and 1mM DTT, pH 4. |
| Solubility: | It is recommended to add 0.1M acetate buffer, pH 4 to prepare a working stock solution of approximately 0.5mg/ml and let the lyophilized pellet dissolve completely. |
| Stability: | Store lyophilized protein at -20°C. Aliquot the product after reconstitution to avoid repeated freezing/thawing cycles. Reconstituted protein can be stored at 4°C for a limited period of time; it does not show any change after two weeks at 4°C. |
| Purity: | Greater than 95.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MKHHHHHHAS QYSSDRCSWK GSGLTHEAHR KEVEQVYLRC AAGAVEWMYP TGALIVNLRP NTFSPARHLT VCIRSFTDSS GANIYLEKTG ELRLLVPDGD GRPGRVQCFG LEQGGLFVEA TPQQDIGRRT TGFQYELVRR HRASDLHELS APCRPCSDTE VLLAVCTSDF AVRGSIQQVT HEPERQDSAI HLRVSRLYRQ KSRVFEPVPE GDGHWQGRVR TLLECGVRPG HGDFLFTGHM HFGEARLGCA PRFKDFQRMY RDAQERGLNP CEVGTD |
METRNL or Meteorin-like protein is a hormone, released after physical activity (in skeletal muscle) or exposure to cold (in adipose tissue), that induces energy rate. METRNL stimulates energy rate correlate with white fat browning and raise glucose tolerance. The protein stimulates different types of immune cells to enter the fat tissue and start their prothermogenic actions.
METRNL Human Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain (a.a 46-311) containing 276 amino acids including a 10 a.a N-terminal His tag. The total molecular mass is 31.2kDa (calculated).
| UniProt Protein Function: | METRNL: Belongs to the meteorin family. |
| UniProt Protein Details: | Protein type:Secreted; Secreted, signal peptide Chromosomal Location of Human Ortholog: 17q25.3 Cellular Component: extracellular space Molecular Function:hormone activity Biological Process: brown fat cell differentiation; fat cell differentiation; negative regulation of inflammatory response; response to cold; response to muscle activity |
| UniProt Code: | Q641Q3 |
| NCBI GenInfo Identifier: | 52345387 |
| NCBI Gene ID: | 284207 |
| NCBI Accession: | NP_001004431.1 |
| UniProt Secondary Accession: | Q641Q3,Q86VM0, B3KSJ5, |
| UniProt Related Accession: | Q641Q3 |
| Molecular Weight: | 31.96kD |
| NCBI Full Name: | meteorin-like protein |
| NCBI Synonym Full Names: | meteorin like, glial cell differentiation regulator |
| NCBI Official Symbol: | METRNL�� |
| NCBI Protein Information: | meteorin-like protein |
| UniProt Protein Name: | Meteorin-like protein |
| UniProt Synonym Protein Names: | Subfatin |
| Protein Family: | Meteorin |
| UniProt Gene Name: | METRNL�� |
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