Human METAP1 Recombinant Protein (RPPB1937)
- SKU:
- RPPB1937
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- P53582
- Research Area:
- Enzymes
Description
| Product Name: | Human METAP1 Recombinant Protein |
| Product Code: | RPPB1937 |
| Size: | 20µg |
| Species: | Human |
| Target: | METAP1 |
| Synonyms: | Methionine aminopeptidase 1, MAP 1, MetAP 1, Peptidase M 1, METAP1, KIAA0094, MAP1A, MetAP1A. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile filtered colorless solution. |
| Formulation: | The METAP1 solution (1mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 3mM DTT, 40% glycerol, 200mM NaCl and 0.1mM PMSF. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 90.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MGSMAAVETR VCETDGCSSE AKLQCPTCIK LGIQGSYFCS QECFKGSWAT HKLLHKKAKD EKAKREVSSW TVEGDINTDP WAGYRYTGKL RPHYPLMPTR PVPSYIQRPD YADHPLGMSE SEQALKGTSQ IKLLSSEDIE GMRLVCRLAR EVLDVAAGMIKPGVTTEEID HAVHLACIAR NCYPSPLNYY NFPKSCCTSV NEVICHGIPD RRPLQEGDIV NVDITLYRNG YHGDLNETFF VGEVDDGARK LVQTTYECLM QAIDAVKPGV RYRELGNIIQ KHAQANGFSV VRSYCGHGIH KLFHTAPNVP HYAKNKAVGV MKSGHVFTIE PMICEGGWQDETWPDGWTAV TRDGKRSAQF EHTLLVTDTG CEILTRRLDS ARPHFMSQF |
Methionine aminopeptidase 1 (METAP1) is a member of the peptidase M24A family. METAP1 removes the amino-terminal methionine from nascent proteins. METAP1 releases N-terminal amino acids, preferentially methionine, from peptides and arylamides. METAP1 is essential for normal progression through the cell cycle. The active site of METAP1 contains 2 adjacent divalent metal ions linked by a water molecule or hydroxide ion.
METAP1 Human Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 409 amino acids (1-386) and having a molecular mass of 45.7kDa.METAP1 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | METAP1: a peptidase that removes the amino-terminal methionine from nascent proteins. |
| UniProt Protein Details: | Protein type:EC 3.4.11.18; Protease Chromosomal Location of Human Ortholog: 4q23 Cellular Component: cytoplasm; cytosol; nucleus Molecular Function:aminopeptidase activity; metalloexopeptidase activity Biological Process: N-terminal protein amino acid modification; peptidyl-methionine modification; regulation of rhodopsin mediated signaling; regulation of translation |
| UniProt Code: | P53582 |
| NCBI GenInfo Identifier: | 33302602 |
| NCBI Gene ID: | 23173 |
| NCBI Accession: | P53582.2 |
| UniProt Secondary Accession: | P53582,B4E2E6, |
| UniProt Related Accession: | P53582 |
| Molecular Weight: | 43,215 Da |
| NCBI Full Name: | Methionine aminopeptidase 1 |
| NCBI Synonym Full Names: | methionyl aminopeptidase 1 |
| NCBI Official Symbol: | METAP1�� |
| NCBI Official Synonym Symbols: | MAP1A; MetAP1A�� |
| NCBI Protein Information: | methionine aminopeptidase 1 |
| UniProt Protein Name: | Methionine aminopeptidase 1 |
| UniProt Synonym Protein Names: | Peptidase M 1 |
| Protein Family: | Methionine aminopeptidase |
| UniProt Gene Name: | METAP1�� |
| UniProt Entry Name: | MAP11_HUMAN |
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