Human MEP1A Recombinant Protein (RPPB3957)
- SKU:
- RPPB3957
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- Q16819
Description
| Product Name: | Human MEP1A Recombinant Protein |
| Product Code: | RPPB3957 |
| Size: | 5µg |
| Species: | Human |
| Target: | MEP1A |
| Synonyms: | Meprin A Subunit Alpha, PABA Peptide Hydrolase,N-Benzoyl-L-Tyrosyl-P-Amino-Benzoic Acid Hydrolase Subunit Alpha, Meprin A,Alpha (PABA Peptide Hydrolase), Endopeptidase-2, EC 3.4.24.18, PPH Alpha,BA268F1.1 (Meprin A Alpha (PABA Peptide Hydrolase)), EC 3.4.24, PPHA, MEP1A. |
| Source: | Sf9 Insect cells |
| Physical Appearance: | Sterile filtered colorless solution. |
| Formulation: | MEP1Aprotein solution (0.25mg/ml) contains Phosphate Buffered Saline (pH 7.4) and 10%glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 85.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | ADPVPIKYLP EENVHDADFG EQKDISEINL AAGLDLFQGD ILLQKSRNGL RDPNTRWTFP IPYILADNLG LNAKGAILYA FEMFRLKSCV DFKPYEGESS YIIFQQFDGC WSEVGDQHVG QNISIGQGCA YKAIIEHEIL HALGFYHEQS RTDRDDYVNI WWDQILSGYQ HNFDTYDDSL ITDLNTPYDY ESLMHYQPFS FNKNASVPTI TAKIPEFNSI IGQRLDFSAI DLERLNRMYN CTTTHTLLDH CTFEKANICG MIQGTRDDTD WAHQDSAQAG EVDHTLLGQC TGAGYFMQFS TSSGSAEEAA LLESRILYPK RKQQCLQFFY KMTGSPSDRL VVWVRRDDST GNVRKLVKVQ TFQGDDDHNW KIAHVVLKEE QKFRYLFQGT KGDPQNSTGG IYLDDITLTE TPCPTGVWTV RNFSQVLENT SKGDKLQSPR FYNSEGYGFG VTLYPNSRES SGYLRLAFHV CSGENDAILE WPVENRQVII TILDQEPDVR NRMSSSMVFT TSKSHTSPAI NDTVIWDRPS RVGTYHTDCN CFRSIDLGWS GFISHQMLKR RSFLKNDDLI IFVDFEDITH LSQHHHHHH |
Meprin A subunit alpha (MEP1A) is a single-pass type I membrane protein which is a member of the peptidase M12A family. MEP1A is abundantly expressed in the kidney and intestinal epithelial cells, is secreted into the urinary tract and intestinal lumen, and found in leukocytes and cancer cells under certain conditions. MEP1A is capable of proteolytically degrading extracellular matrix proteins, proteolytically processing bioactive proteins, and has a role in inflammatory processes.
MEP1A produced in Sf9 Baculovirus cells is a single,glycosylated polypeptide chain containing 589 amino acids (22-601 a.a.) andhaving a molecular mass of 67.4kDa (Molecular size on SDS-PAGE will appear atapproximately 70-100kDa). MEP1A is expressed with a 6 amino acid His tag atC-Terminus and purified by proprietary chromatographic techniques.
| UniProt Protein Function: | MEP1A: Belongs to the peptidase M12A family. |
| UniProt Protein Details: | Protein type:EC 3.4.24.18; Membrane protein, integral; Protease Chromosomal Location of Human Ortholog: 6p12.3 Cellular Component: extracellular space; integral to plasma membrane Molecular Function:protein binding Biological Process: digestion |
| UniProt Code: | Q16819 |
| NCBI GenInfo Identifier: | 153070262 |
| NCBI Gene ID: | 4224 |
| NCBI Accession: | NP_005579.2 |
| UniProt Secondary Accession: | Q16819,Q8TDC9, Q9H1R1, A2RRM4, B0AZP9, B2RCS2, |
| UniProt Related Accession: | Q16819 |
| Molecular Weight: | 84,419 Da |
| NCBI Full Name: | meprin A subunit alpha |
| NCBI Synonym Full Names: | meprin A subunit alpha |
| NCBI Official Symbol: | MEP1A�� |
| NCBI Official Synonym Symbols: | PPHA�� |
| NCBI Protein Information: | meprin A subunit alpha |
| UniProt Protein Name: | Meprin A subunit alpha |
| UniProt Synonym Protein Names: | Endopeptidase-2; N-benzoyl-L-tyrosyl-P-amino-benzoic acid hydrolase subunit alpha; PABA peptide hydrolase; PPH alpha |
| Protein Family: | Meprin |
| UniProt Gene Name: | MEP1A�� |
